Principal Scientist - Reagent Bioinformatics

Roche • Pleasanton, CA

3d • Onsite

About The Position

Roche Sequencing Solutions (RSS) is defining a new class of Next-Generation Sequencing with our proprietary Sequencing by Expansion (SBX) technology. As a Principal Scientist in the Reagent Bioinformatics subchapter, you will help solve unprecedented computational challenges inherent in unexplored molecular workflows and sequencing applications. You can directly influence the trajectory of our state-of-the-art sequencing platform through internal and external collaborations.

Requirements

• Ph.D. in Bioinformatics, Computational Biology, or a related quantitative field.
• In-depth knowledge of NGS, molecular biology, human genomics, and the "why" behind various sequencing modalities.
• Expertise in diverse NGS applications including single cell, spatial transcriptomics, NGS based proteomics preferred.
• Proficiency in Python and workflow managers (Nextflow or Snakemake) within distributed Linux environments, with experience producing well-documented, reproducible code.
• Strong desire to solve unprecedented problems and a commitment to scientific rigor, ensuring routine QC and data tasks are completed with seamless precision.
• Ability to thrive in multi-disciplinary teams and communicate technical findings to audiences of varying technical backgrounds

Responsibilities

• Proactively investigate "first-in-kind" technical challenges in novel sequencing prep and applications on the new SBX platform.
• Design and prototype computational tools for cutting-edge applications where standard pipelines may not apply. Be eager to delve into internal and third-party tools to understand their assumptions and limits.
• Develop a deep understanding of the interplay between reagent chemistry and data quality to recommend iterative improvements for laboratory workflows and bioinformatics pipelines.
• Collaborate closely with wet lab and computational scientists on experimental design, data analysis, QC, and visualization, ensuring high-quality results are communicated clearly across the team.

What This Job Offers

• Job Type: Full-time
• Career Level: Principal
• Education Level: Ph.D. or professional degree