Principal Scientist, Pilot Plant Network and External Manufacturing

Bristol Myers Squibb•Devens, MA

2d•Onsite

About The Position

Bristol-Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases. One shared journey is moving us forward at Bristol-Myers Squibb. Around the world, we are passionate about making an impact on the lives of patients with serious disease. Empowered to apply our individual talents and ideas so that we can learn and grow together. And driven to make a difference, from innovative research to hands-on community support. Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives. The Principal Scientist position will be part of the Scale-up Lab based in Devens, MA and reports to the Director of Pilot Plant Network and External Manufacturing (PPNE). The candidate will be responsible for scale-up and execution of upstream and downstream processes for all assets within the Biologics Development portfolio. The candidate will work closely with the process, analytical and manufacturing teams to improve internal process tech transfer procedures and collaborate on new technology initiatives. In addition, the individual will provide support (on as-needed basis) to external GMP-related activities (investigations, deviations, CAPA, change control) within BD’s external portfolio. Prior experience with Pilot, Manufacturing or Biologics Process development is a plus.

Requirements

Ph.D. in Chemical/Biochemical Engineering, Biochemistry, or related field with 4-6 years of experience; or M.S. with 6-9 years of experience.
Strong knowledge of either Upstream Processing (Mammalian Cell Culture) or Downstream Processing (Harvest, Chromatography and Filtration
Working knowledge of cGMP
Excellent oral and written communication skills
Works well in a team and as an individual

Nice To Haves

Prior experience in single-use manufacturing and automation.
Working knowledge of cGMP is a plus
Knowledge of statistics, design of experiment, and data analysis is desired.

Responsibilities

Lead/support daily operations in the Scale-up Lab, including bioreactor fill/harvest, inoculation, sampling, feeding, operating chromatographic and filtration skids, buffer preparation, run monitoring/troubleshooting
Prepare/review technical documents including campaign summary reports and batch records
Participate in cross-functional teams to support process investigations, process development, scale-up, and tech transfer to clinical and commercial manufacturing
Introduce, evaluate, and implement innovative new process technologies and capabilities
Identify and implement process transfer improvement initiatives with internal stakeholders
Support GMP-related activities for BD External Manufacturing programs (as needed)
Maintain a safe work environment in the Scale-up lab
Works with an operational excellence mindset

Benefits

Health Coverage: Medical, pharmacy, dental, and vision care.
Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
Work-life benefits include: Paid Time Off US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees) Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays Based on eligibility, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day. All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.

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