Principal Scientist, Pharmacokinetics

Merck & Co. • Spring House, PA

295d • Onsite

About The Position

Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity, and teamwork of people like you. To this end, we strive to create an environment of mutual respect, encouragement, and teamwork. As part of our global team, you'll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career. The Department of Pharmacokinetics, Dynamics, Metabolism, and Bioanalytics (PDMB) at Spring House Innovation Park is seeking a highly motivated and experienced Principal Scientist to join the Early Development Vaccines group, with particular focus on developing and running assays in support of Phase I and II trials. The primary role of the successful candidate will be to support and contribute to vaccine analytical strategy, assay development and clinical studies through targeted serological or cell-based bioanalytical assays. The successful candidate will be a scientific leader, with a passion for developing assays, have expertise in immunogenicity, delivering high quality data, and helping teams choose the right assays for data-driven decision making. A record of accomplishment of successful collaboration while working in cross-functional project teams is expected. The successful candidate will also have responsibility for mentoring, scientific supervision, and training scientists.

Requirements

• Ph.D. in biochemistry, molecular/cellular biology/Virology/microbiology or equivalent bio-related science with 8+ years of relevant industry experience.
• M.S. in biochemistry, molecular/cellular biology/Virology/microbiology or equivalent bio-related science with 10+ years industry related experience.
• B.A./B.S. in biochemistry, molecular/cellular biology/Virology/microbiology or equivalent bio-related science with 14+ years of relevant industry experience.
• 8+ years of experience in biochemistry, molecular, cellular biology, virology or microbiology assay development and optimization.
• In-depth understanding of the drug discovery and/or development process and comprehensive knowledge of bioanalytical and/or vaccine clinical testing principles.
• Strong technical expertise in bioanalytical assay design, development and execution.
• Advanced knowledge in immunological assay development (ELISA, our Company, Luminex).
• Trained in GxP as it applies to regulated bioanalysis.
• Ability to understand and implement applicable regulations regarding the use of pathogens.
• Expertise in troubleshooting experimental design, assay development and data analysis.
• Proven ability to lead the development of new, innovative approaches in molecular biology.

Nice To Haves

• Expertise in ELISA, our Company, Luminex or similar immunogenicity assay development.
• Familiar with liquid handlers and other automation platforms for sample preparation and assay process.

Responsibilities

• Support and contribute to vaccine analytical strategy, assay development and clinical studies.
• Develop and run assays in support of Phase I and II trials.
• Deliver high quality data and help teams choose the right assays for data-driven decision making.
• Mentor, supervise, and train scientists.
• Lead the development of new, innovative approaches in molecular biology.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Industry: Chemical Manufacturing
• Education Level: Ph.D. or professional degree