As a (Senior) Principal Scientist in the Protein Design and Informatics (PDI) team, you will focus on translating biological mechanisms of disease to molecular mechanisms of therapeutics by integrating perturbation data to design new molecules that modulate disease phenotypes. The advancement in de novo design technologies has opened the doors to generate molecules to test biological hypotheses at scale, build up foundational data to predict new perturbation effects, accelerate the validation of disease intervention points, and drive therapeutic discovery campaigns. Included in the larger Data, Automation, and Predictive Sciences (DAPS) department, you will be the predictive engine for R&D, focusing on researching and embedding new methods to enable the vision of automation of the entire Design-Make-Test-Analyze cycle, driving Lab-in-an-Automated-Loop frameworks from target discovery to the clinic - all stages of a therapeutic project. You'll have the opportunity to work in close partnership with many departments across GSK, developing and fostering a high-performing team culture of collaboration, curiosity, consistency, agility, quality, peer review, and continuousâ improvement with a relentless focus on creating medicines for patients. We create a place where people can grow, be their best, be safe, and feel welcome, valued and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme. We embrace modern work practises; our Performance with Choice programme offers a hybrid working model, empowering you to find the optimal balance between remote and in-office work.