Principal Scientist, Medicinal Chemistry

Vividion Therapeutics, Inc•San Diego, CA

2h•$165,000 - $180,000

About The Position

As a senior member of the Vividion chemistry department, the successful candidate will be able to contribute to all priority phases of the drug discovery process including library growth, hit identification, hit to lead, and guide lead optimization programs to successful Development Candidate nominations and IND submissions. The preferred candidate will be comfortable balancing traditional approaches, exploring novelty on the cutting edge of modern small-molecule drug discovery, and have a thirst to constantly learn.

Requirements

PhD in synthetic organic chemistry with 8+ years of industry experience in small molecule drug discovery with a clear understanding of program strategy, therapeutic hypothesis, assay relevance and clinical translation, and the importance of physical-chemical properties as it relates to enabling late-stage in vivo studies and clinical dosing.
A clear command of classical and modern synthetic methodology and reaction mechanism.
Expertise to craft compounds that fully exploit insights from ligand and/or structure-based design while fully exploiting all available synthetic methods.
Proven leadership skills within and across multiple functions as part of integrated drug discovery teams as exemplified by delivery of development candidate small molecules.
Experience in mentoring and managing both internal junior chemists and outsource chemistry resources.
Excitement and unhesitating commitment to advance a rapidly growing biotech organization in any way necessary including from the lab as needed.
Curiosity
Fearlessness
Creativity
Attention to detail
Willingness to challenge dogma