Principal Scientist, In Vivo Pharmacology, Oncology Discovery Biology

Bristol Myers Squibb • VA

117d • $156,180 - $189,252

About The Position

Working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. The Oncology Thematic Research Center at BMS is a key research and early development engine, responsible for the discovery and development of novel oncology therapeutics for patients. Centered at our state-of-the-art research sites in Cambridge and Seattle, scientists focus on novel targets and pathways for tumors that are refractory to current therapies. We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex-vivo models of Cancer biology and Immuno-oncology to identify and validate targets.

Requirements

• Bachelor’s Degree with 8+ years of academic and/or industry experience, or a Master’s Degree with 6+ years of experience, or a Ph.D. or equivalent advanced degree in the Life Sciences with 4+ years of experience.
• Demonstrated ability to independently develop focused in vivo strategies and utilize PK/PD/efficacy data.
• Demonstrated leadership in developing and deploying novel in vivo models.
• Hands-on experience using various cell line and PDX mouse models, humanized mouse models, admixture xenografts, orthotopic models.
• Demonstrated expertise in utilizing relevant pharmacodynamic assays such as MSD ELISAs, Luminex and immune profiling by flow cytometry.
• Excellent interpersonal and communication skills.

Nice To Haves

• PhD in immunology, cancer biology or relevant biological science with 4+ years of relevant industry experience in in vivo pharmacology.
• Industry experience with a proven track record of independently driving in vivo strategy for immune cell engagers.
• Familiar with PET/CT, IVIS and other novel imaging approaches.

Responsibilities

• Function as Pharmacology lead as well as provide support for T cell engager drug discovery programs.
• Lead the development of in vivo strategies from target concept to Proof of Concept in patients.
• Demonstrate critical thinking to address project challenges and independently drive the program forward.
• Characterize drug candidates in vivo as part of the lead selection process.
• Identify and develop state of the art in vivo models, experimental protocols and relevant assays.
• Work with cross-functional teams to develop and implement program strategy.
• Design, independently execute and deliver experiments with comprehensive high quality data sets.
• Interpret results of complex experiments.
• Proactively foster relationships across disciplines to facilitate decision making process.
• Prepare and present comprehensive technical or project updates in team meetings and other forums.
• Lead initiatives related to development of new approaches / technologies within T-Cell engager strategy.

Benefits

• Medical, pharmacy, dental and vision care.
• Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP).
• Financial well-being resources and a 401(K).
• Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance.
• Work-life programs including paid national holidays, up to 120 hours of paid vacation, and sick time off.
• Parental, caregiver, bereavement, and military leave.
• Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits.
• Tuition reimbursement and a recognition program.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree
• Number of Employees: 5,001-10,000 employees