Principal Scientist, Immuno-Oncology
About The Position
SystImmune is a leading and well-funded clinical-stage biopharmaceutical company located in Redmond, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). SystImmune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials. SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discover and IND-enabling stages, representing cutting-edge biologics development. We offer an opportunity for you to learn and grow while making significant contributions to the company's success. This on-site laboratory role is in the research and development group. The ideal candidate is a highly energetic and motivated Principal Scientist with experience in discovery and development of protein therapeutics. The position requires a strong background in immunology oncology, and tumor biology, as well as hands-on experience with major biotechnology platforms for biologics drug development.
Requirements
- PhD in Immunology, Cancer Biology, or related field with 5-10+ years relevant academic and/or biotech/pharma experience.
- Strong background in immune cell biology, T cell functional assay development, antibody-based drugs, and receptor signaling.
- Demonstrated expertise in immuno-oncology preclinical models and mechanism-driven in vitro assays using primary human immune cells (e.g., functional co-cultures, flow cytometry phenotyping, cytokine profiling).
- Experience advancing antibody-based therapeutics, with bispecific/multispecific and/or combination program experience preferred.
- Proven ability to lead cross-functional teams, mentor others, and communicate clear, data-driven recommendations.
- Strong organizational skills and a collaborative, agile “can-do” mindset.
Responsibilities
- Design, establish, and execute mechanism-driven in vitro and in vivo preclinical models (including ex vivo / human translational systems as appropriate) to identify and characterize novel immuno-oncology antibody therapeutics.
- Develop fit-for-purpose functional assays aligned to proposed MOA (e.g., immune cell activation, cytotoxicity, cytokine profiles, phenotyping) and define appropriate controls, acceptance criteria, and decision-making metrics.
- Drive target and pathway evaluation and translate immunobiology into therapeutic hypotheses; propose and assess bispecific, multi-specific, and combination strategies with clear differentiation and risk-mitigation plans.
- Serve as a scientific leader on cross-functional teams (Protein Engineering, Antibody Discovery, Analytical) to align on molecule design requirements, assay plans, and program milestones.
- Mentor and guide junior scientists; set technical direction, ensure high-quality execution, and champion rigorous experimental design, documentation, and reproducibility.
- Author high-quality study reports, protocols, and presentations; communicate program strategy and data to internal governance and external partners as needed.
- Contribute to IND-enabling documentation by providing clear scientific rationale, study summaries, and data interpretation for regulatory submissions (domestic and international).
- Lead immuno-oncology preclinical project(s), including timelines, resourcing, and risk/issue management; drive decisions that enable progression to development.
- Other duties as assigned.
Benefits
- SystImmune offers a comprehensive benefits package including: 100% paid employee premiums for medical/dental/vision, also STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 11 paid holidays and MORE.
- We offer an opportunity for you to learn and grow while making significant contributions to the company’s success.
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What This Job Offers
Job Type
Full-time
Career Level
Principal
Education Level
Ph.D. or professional degree
Number of Employees
11-50 employees
