Principal Scientist, High-Throughput Sequencing
About The Position
We are seeking a Principal Scientist, High-Throughput Sequencing to lead the design, development, and optimization of next-generation sequencing (NGS)-based assays for molecular residual disease testing (MRD). The ideal candidate is an innovative scientist with deep expertise in sequencing technologies, assay development, and data-driven decision-making who thrives at the interface of research, engineering, and clinical translation. This individual will serve as a technical leader, mentor, and strategic contributor within our growing R&D organization.
Requirements
- Ph.D. in Molecular Biology, Genomics, Biochemistry, Bioengineering, or a related field.
- 8+ years of experience in high-throughput sequencing assay development (academic, biotech, or diagnostics).
- Demonstrated expertise in NGS library prep, target enrichment, barcoding/multiplexing, and sample QC.
- Strong track record of assay development and technology transfer into clinical or commercial labs.
- Experience analytically validating NGS assays including writing validation plans and reports
- Familiarity with bioinformatics pipelines and statistical principles for NGS assay validation.
- Excellent communication skills, with a proven ability to lead cross-functional teams and mentor scientists.
Responsibilities
- Lead the development and optimization of high-throughput sequencing assays, with a focus on sensitivity, specificity, and scalability for clinical deployment.
- Evaluate and implement emerging sequencing technologies (short-read, long-read, single-cell, or spatial omics) to enhance assay performance.
- Collaborate cross-functionally with bioinformatics, automation engineering, and clinical development teams to design robust end-to-end workflows.
- Design and oversee analytical validation studies, including assay reproducibility, limit of detection, and dynamic range.
- Drive innovation strategy in sequencing, staying abreast of new chemistries, platforms, and library preparation methods relevant to diagnostics.
- Mentor junior scientists and research associates, fostering technical excellence and career growth.
- Author scientific publications, presentations, and contribute to regulatory submissions (CLIA/CAP/FDA).
Benefits
- Competitive Compensation and company wide benefits plan
- Opportunities for career advancement and professional development.
- A collaborative and innovative work environment dedicated to improving oncology outcomes.
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What This Job Offers
Job Type
Full-time
Career Level
Principal
Education Level
Ph.D. or professional degree
Number of Employees
11-50 employees
