Principal Scientist (DMPK)

Zai Lab • South San Francisco, CA

158d • $156,000 - $182,000

About The Position

The Principal Scientist, DMPK, is a senior scientific contributor who provides expert support to drug discovery and development programs. This role focuses on designing and executing DMPK studies, interpreting data, and collaborating cross-functionally, while aligning with the strategic direction set by the Executive Director.

Requirements

• PhD degree with five years of relevant industry experience; or equivalent combination of education, training and experience.
• Proficiency in reading and writing in both Chinese and English.

Nice To Haves

• Deep understanding of PK and ADME concepts.
• Extensive hands-on experience in pharmacokinetics, with a proven ability to design and interpret studies independently.
• Proficiency in Phoenix or other advanced data management and modeling software tools.
• Strong background in PK/PD analysis, design, interpretation, and simulation.
• Hands-on experience in the development of bioanalytical methods in support of preclinical PK studies for large molecules.
• Excellent oral and written communication skills.
• Excellent interpersonal skills and ability to work in a team environment.
• Alignment with Zai Lab's core values of excellence, patient-centered care, and collaboration; must be resourceful, self-driven, and thrive in a dynamic, fast-paced environment.
• Unwavering commitment to the highest standards of personal integrity and professional ethics.

Responsibilities

• Independently design and oversee in vivo pharmacokinetic studies in preclinical species; author and critically review study protocols to ensure scientific rigor.
• Lead coordination and collaboration with CROs and internal cross-functional teams to secure quotes, manage study materials, provide expert scientific input, and ensure high-quality execution of study activities.
• Provide advanced problem-solving expertise in the development of bioanalytical methods and the analysis of samples for large molecules.
• Perform and guide pharmacokinetic data analysis using Phoenix, ensuring accuracy and relevance to program goals.
• Interpret complex pharmacokinetic/pharmacodynamic (PK/PD) data to support both discovery and development-stage projects.
• Effectively communicate and present PK findings to cross-functional program teams, influencing decision-making and strategy.
• Actively contribute to and provide scientific leadership within discovery and development project teams.
• Play a key role in the preparation and critical review of study reports and regulatory documents, ensuring alignment with submission standards and timelines.

Benefits

• Base pay range between $156K and $182K/year.
• Sign-on bonus.
• Restricted stock units.
• Discretionary awards.
• Full range of medical benefits.
• 401(k) eligibility.
• Various paid time off benefits, such as vacation, sick time, and parental leave.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Industry: Professional, Scientific, and Technical Services
• Education Level: Ph.D. or professional degree