Principal Scientist, Discovery DMPK Bioanalytical

GSK•Upper Providence Township, PA

About The Position

Are you looking to apply your mass spectrometry skills to solve challenging bioanalytical problems and help drive discovery programs forward, helping patients across the globe. As a Discovery DMPK bioanalyst, you will be part of a team responsible for the analysis of molecules spanning GSK’s portfolio. Using state of the art equipment, we work with compounds at stages from early discovery to development in a fast-paced discovery laboratory environment. In this role you will have opportunities to utilize, challenge, and expand your bioanalytical skill set while planning and building our LC-MS capabilities for biologics. In this position, you will have the opportunity to plan, develop, and execute on our objective to provide the large molecule LC-MS analyses required by our evolving portfolio. Working across boundaries, you will help define the trajectory of our LC-MS approaches for biologics, collaborating cross-functionally to understand areas of need and delivering to those goals. By establishing best practices for sample preparation, quantitation strategies, and data analysis you will drive projects forward while building organizational expertise in biopharmaceutical bioanalysis. Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale. People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

Requirements

Ph.D. in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or a related discipline, with 2+ years of postdoctoral/industry experience; or M.S. with 5+ years; or B.S. with 8+ years.
Experience in mass spectrometry -based analysis of biopharmaceutics (e.g., antibodies, antibody-drug conjugates)
Experience in implementing new instrumentation, technology, and workflows to solve challenging analytical problems
Experience with high resolution mass spectrometry instrumentation and data analysis
Laboratory experience analyzing DMPK/related assays (in vitro, in vivo, toxicokinetic) using mass spectrometry

Nice To Haves

Proficient in using and troubleshooting Sciex mass spectrometers, including Time-of-Flight instruments
Experience with the bioanalysis of oligonucleotide therapeutics (siRNA, ASOs, or related modalities)
Prior involvement in matrix leadership, including leading cross-functional initiatives or guiding scientific strategy across multiple teams.
Familiarity with regulatory expectations for large molecule bioanalysis.

Responsibilities

Working within the Discovery DMPK group, you will utilize your lab-bench technical knowledge and apply your experience in LC-MS approaches to support GSK’s portfolio deliverables.
This role will work across modalities (large/small molecule, oligonucleotides, etc.) but provide key leadership as a subject matter expert in large molecule LC-MS bioanalysis.
plan, develop, and execute on our objective to provide the large molecule LC-MS analyses required by our evolving portfolio.
Working across boundaries, you will help define the trajectory of our LC-MS approaches for biologics, collaborating cross-functionally to understand areas of need and delivering to those goals.
By establishing best practices for sample preparation, quantitation strategies, and data analysis you will drive projects forward while building organizational expertise in biopharmaceutical bioanalysis.

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