Principle Scientist - Discovery Biomarker

Amgen • South San Francisco, CA

1d

About The Position

Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Principal Scientist - Discovery Biomarkers What you will do Let’s do this. Let’s change the world. In this vital role you will focus on the discovery of biomarkers to support the progression of therapeutic candidates from discovery to early clinical development. The Amgen Discovery Biomarkers group is looking for an innovative Principal Scientist, dedicated to biomarker discovery in the areas of inflammation and rare disease. This Principal Scientist will work cross-functionally and interact closely with both the development and research groups.

Requirements

• Doctorate degree PhD, PharmD, MD with relevant postdoctoral experience and 2 years of Discovery Biomarkers experience OR Master’s degree and 5 years of Discovery Biomarkers experience OR Bachelor’s degree and 7 years of Discovery Biomarkers experience

Nice To Haves

• PhD or MD PhD, with postdoctoral training and industry experience in the fields of immunology (must have), cell and molecular biology, or biochemistry. Biomarker Clinical Development experience is preferred.
• Demonstrated track record of independent critical thinking and scientific achievement in the areas of cell and molecular biology and biochemistry as demonstrated by multiple high impact publications
• Demonstrated experience in leading independent research and/or drug development
• Experience with implementing multiple technology platforms
• Strong verbal and written communication skills. Ability to collaborate and troubleshoot to solve problems
• Experience working in teams, managing scientists and consistently delivering results

Responsibilities

• Develop comprehensive disease area expertise for key indications within the inflammation therapeutic area
• Support strategic initiatives by providing deep scientific knowledge of inflammatory pathways and mechanisms
• Stay current with emerging research and therapeutic approaches in inflammatory diseases
• Identify, evaluate, and prioritize relevant target engagement biomarkers for inflammatory conditions
• Define quantitative thresholds for biomarker efficacy and clinical relevance
• Integrate exposure data with pharmacodynamic modulation information to create comprehensive temporal profiles
• Design and execute biomarker discovery strategies across multiple programs using real-world, clinical, and preclinical data
• Demonstrate exceptional thoroughness and expertise when conducting complex immunology-related assays
• Generate high-quality pharmacodynamic data to inform clinical development decisions
• Assess population heterogeneity through sophisticated biomarker measurements
• Support companion diagnostic test development when required for targeted therapies
• Evaluate the applicability and relevance of preclinical findings from model systems to human contexts
• Bridge the gap between laboratory discoveries and clinical applications
• Support translational biomarker activities for therapeutic assets, including participation in investigator meetings and advisory boards
• Collaborate on investigator-sponsored studies for correlative biomarker research alongside Clinical Biomarker leads
• Work effectively in a highly matrixed environment to drive scientific and technical innovation
• Collaborate with cross-functional teams in Inflammatory Diseases, Clinical Biomarker & Diagnostics, Therapeutic Discovery, Human Genetics, and Computational Biology
• Mentor laboratory scientists to ensure generation of high-quality, reliable experimental data
• Provide scientific leadership and guidance to junior team members

Benefits

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible.

What This Job Offers

• Job Type: Full-time
• Career Level: Principal
• Education Level: Ph.D. or professional degree