Principal Scientist - Clinical Pharmacology, Modeling & Simulation

Amgen • South San Francisco, CA

112d • Remote

About The Position

Join Amgen's Mission of Serving Patients. At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas -Oncology, Inflammation, General Medicine, and Rare Disease- we reach millions of patients each year. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Requirements

• Doctorate degree and 2 years of Clinical Pharmacology and Modeling & Simulation experience, or
• Master's degree and 4 years of Clinical Pharmacology and Modeling & Simulation experience, or
• Bachelor's degree and 6 years of Clinical Pharmacology and Modeling & Simulation experience, or
• Associate's degree and 10 years of Clinical Pharmacology and Modeling & Simulation experience, or
• High school diploma / GED and 12 years of Clinical Pharmacology and Modeling & Simulation experience.

Nice To Haves

• PhD in Pharmacokinetics, Pharmaceutical Sciences, Pharmacology, Chemical Engineering, or equivalent professional degrees.
• 5+ years of experience in Clinical Pharmacology, Modeling & Simulation in the Biotechnology/Pharmaceutical Industry.
• Hands-on experience in Quantitative Clinical Pharmacology approaches with a focus on PK/PD modeling, M-PBPK modeling, M-PBPK-PD modeling, and QSP modeling.
• Established track-record of Model Based Drug Development (MIDD).
• Experience in leading the design and implementation of clinical pharmacology and biopharmaceutic studies.

Responsibilities

• Drive innovative modeling and simulation strategies for translational approaches to support clinical dosage selections and clinical study designs.
• Apply Quantitative Translational and Clinical Pharmacology approaches such as PK/PD modeling, M-PBPK modeling, M-PBPK-PD modeling, and QSP modeling.
• Integrate emerging Machine Learning and Generative AI approaches to guide optimal clinical drug development.
• Serve as a Subject Matter Expert in Clinical Pharmacology and Modeling & Simulation.

Benefits

• Comprehensive employee benefits package including health and welfare plans for staff and eligible dependents.
• Retirement and Savings Plan with generous company contributions.
• Group medical, dental and vision coverage.
• Life and disability insurance, and flexible spending accounts.
• Discretionary annual bonus program.
• Stock-based long-term incentives.
• Award-winning time-off plans.
• Flexible work models, including remote and hybrid work arrangements.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Industry: Chemical Manufacturing
• Education Level: Ph.D. or professional degree