Principal Scientist, Bioassay and Impurity Assay Development

Bristol Myers Squibb • New Brunswick, NJ

1d • Onsite

About The Position

Bristol Myers Squibb is a global leader in Biotherapeutics for Immuno-Oncology. The Potency and Impurity Analytical Development department serves as the central hub for biological potency assay and impurity assay development, comprehensive biological characterization, and clinical lot release. In support of our expanding biologics pipeline, we are seeking seasoned professionals who are dedicated to advancing recombinant therapeutics to address critical unmet medical needs. The Principal Scientist will lead the development of advanced potency and impurity assays to support the company’s portfolio of preclinical and clinical-stage biologics. This position demands a deep understanding of cell biology, immunology, and molecular biology, as well as expertise in designing and developing cell-based assays for protein function analysis. Success in this role requires strong collaboration with early discovery, process sciences, analytical teams, Manufacturing Sciences and Technology, and Quality Control.

Requirements

• PhD in Immunology, Cell Biology, Molecular Biology, or a related scientific discipline with 4–6 years of relevant industry experience; or a Master’s degree with 6–9 years of experience; or a Bachelor’s degree with 9–12 years of experience.
• Typically possesses 4–6+ years of direct experience in biopharmaceutical development.
• Demonstrated strong scientific expertise in cell-based assay development.
• Experience in developing CMC strategies for potency and/or impurities.
• Proficiency in developing ELISA methods for QC lot release of potency and impurities.
• Detail-oriented and committed to delivering high-quality results.
• Excellent interpersonal and communication skills.
• Knowledge of regulatory and compliance guidelines.

Nice To Haves

• Experience with BIACORE or FACS is highly desirable.

Responsibilities

• Serve as the primary lead for bioassay development across both early and late stage development programs, including design and qualification of assays for biological characterization and validation, and partner closely with stakeholders across the organization.
• Oversee experimental planning, execution, data review and analysis, technical documentation, and contribute to regulatory submissions.
• Participate in the formulation of analytical control strategies; proactively address technical, regulatory, and business requirements.
• Ensure comprehensive documentation of results and maintain laboratory instrumentation in compliance with GMP standards.
• Promote innovation, scientific and operational excellence, and continuous learning within the team.

Benefits

• Health Coverage: Medical, pharmacy, dental, and vision care.
• Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
• Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
• Work-life benefits include: Paid Time Off US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees) Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays Based on eligibility, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day. All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.
• The summer hours program is for United States (U.S.) office-based employees due to the unique nature of their work. Summer hours are generally not available for field sales and manufacturing operations and may also be limited for the capability centers. Employees in remote-by-design or lab-based roles may be eligible for summer hours, depending on the nature of their work, and should discuss eligibility with their manager. Employees covered under a collective bargaining agreement should consult that document to determine if they are eligible. Contractors, leased workers and other service providers are not eligible to participate in the program.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree