Principal Scientist, AI Protein Sciences (Discovery Platforms & Automation)

Systimmune•Redmond, WA

1d•$150,000 - $200,000

About The Position

SystImmune is a leading and well-funded clinical-stage biopharmaceutical company located in Redmond, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). SystImmune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials. SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discover and IND-enabling stages, representing cutting-edge biologics development. We offer an opportunity for you to learn and grow while making significant contributions to the company's success. SystImmune is seeking a Principal Scientist to lead the design, implementation, and ownership of a next-generation automated protein sciences platform supporting biologics discovery. This role will focus on building scalable capabilities in cell-free protein expression, purification, high-throughput binding characterization, sample handling and data analysis through the integration of AI, laboratory automation and robotics. This position is ideal for a scientist who has experience building or significantly expanding experimental platforms and wants to take technical ownership of automation strategy, technology selection, workflow architecture, and scientific execution. The individual will operate as a technical leader responsible for establishing platform capabilities that accelerate protein and antibody discovery programs. This role combines hands-on experimental science, platform strategy, capital planning, and scientific leadership, with future opportunity to build and mentor a small team.

Requirements

PhD in Biochemistry, Structural Biology, Biophysics, Molecular Biology, Bioengineering, or related field
6+ years of industry experience in protein sciences, biologics discovery, or related field
Deep expertise in protein expression, purification, and binding characterization assays
Experience applying structural biology to protein design, characterization, or discovery workflows
Experience with cell-free protein expression systems
Proven experience evaluating, selecting, purchasing, and implementing cell free system, laboratory automation or robotic liquid handling systems (required)
Demonstrated experience building or scaling automated experimental workflows
Strong understanding of protein structure and structure-function relationships
Experience leading technical platforms, complex scientific initiatives, or infrastructure buildouts
Demonstrated ability to independently drive new technical capabilities from concept to execution
Candidates must have prior experience selecting and implementing at least one major laboratory automation or robotic system in an industry environment.

Nice To Haves

Prior experience applying protein science platforms within drug discovery or biologics development environments
Experience supporting antibody, protein engineering, or biologics discovery programs
Familiarity with high-throughput screening technologies or discovery platform environments
Experience integrating laboratory automation with data infrastructure such as LIMS or experimental data systems
Working knowledge of computational biology approaches, including protein modeling or structure prediction tools
Demonstrated mentorship of scientists or contribution to building technical teams
Hands-on experience with structural biology techniques such as cryo-EM, X-ray crystallography, or related modeling tools

Responsibilities

Lead the design and buildout of an automated protein sciences platform from concept through implementation
Evaluate, select, and implement robotic systems, liquid handlers, and supporting automation infrastructure
Define workflows for protein production, purification, and characterization to maximize throughput and reproducibility
Establish best practices for automation integration into discovery workflows
Serve as the scientific and technical owner of the platform
Design and execute protein science workflows including: Cell-free protein expression systems Protein purification (affinity, ion exchange, SEC) Binding characterization assays (BLI, SPR, ELISA, Octet) Biophysical characterization techniques
Apply structural biology knowledge to guide construct design and protein optimization strategies
Interpret structure-function relationships to guide discovery decisions
Drive experimental strategy supporting therapeutic protein programs
Develop automated workflows for protein expression, purification, and assay execution
Partner with vendors and internal stakeholders to deploy new technologies
Identify opportunities to improve throughput, quality, and reproducibility through automation
Establish data workflows supporting automated experimentation
Define equipment strategy and capital investment priorities
Lead vendor evaluations and purchasing decisions
Manage platform budget and equipment planning
Design laboratory processes ensuring efficient system integration
Partner with computational biology teams to integrate modeling and experimental workflows
Work closely with antibody discovery, protein engineering, and translational teams
Support integration of experimental data into discovery decision making
Contribute to strategic platform development supporting pipeline growth

Benefits

SystImmune offers a comprehensive benefits package including: 100% paid employee premiums for medical/dental/vision, also STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 11 paid holidays and MORE.

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