Principal Research Scientist I (Manager), Analytical R&D

AbbVie • North Chicago, IL

281d

About The Position

For the Principal Research Scientist I position, we are seeking a highly motivated, experienced analytical scientist to lead a team of analytical scientists supporting early phase development of small molecule New Chemical Entities (NCEs) drug substance and drug product in both preclinical and clinical programs. The candidate should have extensive expertise in applying regulatory guidelines within an R D environment with a fit for purpose mind set. The candidate will need experience in analytical control strategies, analytical method development, characterization, validation, release, and stability testing. He/ She should be able to direct research and/or project activities by effectively mentoring, guiding and/or supervising scientific personnel. Should conceive, execute and communicate novel multi-disciplinary research or development strategies that achieve project and strategic goals. Serve as a lead scientist on projects and contribute scientific insights into multiple other projects and initiatives. He/she must foster productive collaborations within the global Analytical R D organization and with R D cross-functional partners such as Pre-Clinical Safety (PCS), Process Chemistry, Process Engineering, Drug Product Development (DPD), and Quality Assurance (QA) and CMC-Regulatory.

Requirements

• Bachelors, Masters, or Ph.D. in Analytical Chemistry typically with a minimum of 14 (BS), 12 (MS), or 6 (Ph.D.) years related industry experience.
• Demonstrated people-management experience.
• Strong technical background in analytical chemistry, excellent analytical problem-solving skills.
• Capable of independently developing and troubleshooting analytical methods.
• Demonstrate creative 'out of the box' thinking to solve difficult problems.
• Champion new technologies to achieve project goals.
• Hands-on experience with HPLC analysis and method development along with fundamental understanding and working knowledge of various analytical techniques including MS, GC, ICP-OES, IC, and NMR.
• Self-motivated, hard-working, detail-oriented individual able to work in a fast-paced team environment.
• Experience in the use of computerized data handling systems.
• High-quality written and oral communication skills and ability to interact effectively with interdisciplinary scientists and engineers.
• Learns fast, grasps the 'essence' and can change course quickly where indicated.

Responsibilities

• Mentor/supervise a team to support the development of NCE candidates (RSM to API to DP) from pre-clinical through Phase II clinical trials and accountable for the effective performance of the team/individuals.
• Responsible for method development, testing procedures, and implementation of analytical control strategies to help the advancement of drug discovery candidates.
• Apply analytical separation and detection modes for complex impurity profiling of pharmaceutical products to further the understanding of emerging cGMP manufacturing processes.
• Generate new scientific proposals and lead those efforts.
• Anticipate and critically evaluate scientific or regulatory advances or competitive threats and respond with appropriate new strategies.
• Utilize understanding of a range of analytical techniques to conduct research and development studies related to small-molecule drug products, active pharmaceutical ingredients, intermediates, starting materials, impurities and impurity profiling.
• Routinely demonstrate scientific initiative and creativity in research or development activities and maintain a high level of productivity in the lab.
• Embrace the ideas of others, nurture innovation and manage innovation to reality.
• Encourage ideas and drive for continuous improvement and champion initiatives within Analytical R D and across R D partner functions.
• Understand and comply with AbbVie safety, quality and regulatory policies and government regulations.

Benefits

• Paid time off (vacation, holidays, sick)
• Medical/dental/vision insurance
• 401(k) to eligible employees
• Short-term incentive programs
• Long-term incentive programs

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Industry: Chemical Manufacturing
• Education Level: Ph.D. or professional degree