Principal Research Associate, Mass Spectrometry

Foghorn Therapeutics • Watertown, MA

4d

About The Position

This role will support drug discovery efforts through research‑driven, MS–based analytical method development and deep scientific problem‑solving. It will contribute to advancing discovery programs through hands-on operation of instrumentation, development and execution of analytical workflows, and close collaboration with cross-functional scientists across research teams.

Requirements

• Bachelor’s or Master’s degree in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or a related field.
• 3+ years of relevant laboratory experience in mass spectrometry, biochemistry, or analytical chemistry in a drug discovery, pharmaceutical, or biotechnology setting.
• Experience operating LC-MS, LC-MS/MS, or related analytical instrumentation, with a strong interest in hands-on instrument operation, maintenance, and troubleshooting.
• Demonstrated experience in research‑focused experimental work, such as assay development, method refinement, or troubleshooting complex datasets, beyond analytical testing.

Nice To Haves

• Experience developing and optimizing LC‑MS analytical methods, including innovating new research assays, adapting techniques to novel targets, or working through complex, non‑routine analytical challenges.
• Familiarity with intact MS, proteomics, or related mass spectrometry workflows.
• Experience with software tools for MS data processing and analysis.

Responsibilities

• Perform mass spectrometry–based analyses (e.g., proteomics, intact MS) to characterize small molecules, protein interactions, and other targets relevant to drug discovery programs.
• Operate, maintain, and troubleshoot analytical instrumentation, including LC-MS and related platforms.
• Develop, optimize, and execute analytical methods and exploratory assays, to support compound characterization, screening activities, and project workflows.
• Analyze and interpret experimental data, prepare summaries, and communicate results to cross-functional project teams.
• Collaborate with scientists across chemistry, biology, and pharmacology to advance discovery programs and provide mass spectrometry expertise.
• Contribute to experimental planning, documentation, reporting, and ownership of analytical workflows supporting research activities.

Benefits

• Highly competitive and inclusive medical, dental and vision coverage options
• FSA and HSA for medical expenses and dependent care expenses
• Free premium access to fitness, nutrition, and mindfulness classes
• Unlimited paid time off policy
• Discretionary winter shut down
• Generous Paid Leave offerings, including 12 weeks of 100% paid parental leave
• Paid Life, LTD and STD insurance coverages, as well as voluntary benefit options
• Free parking or subsidized commuter passes

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level