Calico seeks a Principal Program Manager to closely collaborate with and support senior research leaders, including the CSO, Head of Research, and Head of Human Biology and Genetics, to facilitate new administrative initiatives and our innovative programs. The Principal Program Manager will be involved in the planning and execution of upcoming projects and research programs. The Principal Program Manager will work collaboratively with the Finance and Program Management teams to track ongoing activities and develop processes and systems for forecasting and prioritization. Projects will include implementation of new project review committees, implementation of cross functional collaborations, and other corporate initiatives. The Principal Program Manager will be expected to develop an understanding of existing and upcoming projects and will be responsible for identifying dependencies between projects and individuals involved to ensure alignment on expectations, deadlines, resourcing, and budgeting; and to facilitate clear communication among the relevant stakeholders. The Principal Program Manager will coordinate with other Project Managers to ensure efficient operations across all divisions of the company. The successful candidate will be able to effectively balance a high-level strategic view across Research programs with meticulous attention to detail of individual projects. The Principal Program Manager will report directly to the CSO.