Principal Investigator – Clinical Research

QPS, LLC•Springfield, MO

2d•Onsite

About The Position

QPS is seeking an experienced Principal Investigator (PI) to provide senior clinical leadership within its research unit. This role is well suited for a seasoned investigator who enjoys combining hands-on study responsibility with broader clinical oversight, continuity, and mentorship. The PI will lead assigned studies while also serving as a trusted clinical resource and back-up for PRN and Contract PIs, helping ensure consistent study conduct, regulatory compliance, and subject safety across the portfolio. This position is 100% office/lab based at QPS in Springfield, MO and offers meaningful influence over study quality and execution. QPS’ Story: Since its inception, QPS has been assisting pharmaceutical, biotechnology and medical device companies with their drug development efforts by providing a full range of Neuropharmacology, DMPK, Toxicology, Bioanalysis, Translational Medicine, Early Phase Clinical and Phase II – IV Clinical Research services. To meet the needs of our clients, we strive to employ talented, caring and committed individuals who will work collaboratively towards achieving our mission of improving human health and the quality of life. If this sounds like your ideal work environment, then we would love to speak with you, so apply today! Please visit our website (www.qps.com) for more information and to see all current openings.

Requirements

MD or DO (Board Certified)
Strong working knowledge of ICH-GCP and clinical research regulations
Experience leading clinical studies as a PI or Sub-Investigator
Comfortable operating with a high degree of autonomy while collaborating across teams
Excellent written and verbal communication skills
Proficiency with MS Office and standard clinical research systems
Ability to work a flexible schedule, including occasional nights, weekends, and holidays

Nice To Haves

Endocrinology expertise or therapeutic-area experience strongly preferred
Candidates with a strong endocrinology background will be considered even without prior CRO experience

Responsibilities

Lead clinical trials in accordance with ICH-GCP, federal and state regulations, and approved protocols
Provide senior clinical oversight and continuity across studies supported by PRN and Contract PIs
Serve as back-up PI as needed to support uninterrupted study conduct
Ensure subject safety, rights, and confidentiality at all times
Oversee and participate in the informed consent process, ensuring clarity, compliance, and documentation integrity
Confirm that all subjects meet 100% of inclusion and exclusion criteria prior to dosing
Guide, mentor, and provide clinical input to PRN and Contract PIs and study staff
Ensure appropriate delegation, training, and maintenance of essential trial documentation
Act as a primary point of contact with sponsors, IRBs, monitors, and auditors
Participate in investigator meetings, monitoring visits, audits, and inspections

Benefits

This role offers an opportunity to apply deep clinical expertise in a setting that values judgment, continuity, and scientific rigor.
You’ll remain directly involved in study conduct while helping shape how trials are executed across the unit—without the administrative weight of formal people management.
For experienced PIs, QPS provides a platform to focus on quality, mentorship, and meaningful clinical impact, while working closely with sponsors and multidisciplinary teams in a collaborative, well-supported research environment.

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