Principal Investigator (Physician - Internal Medicine)

ALLIANCE CLINICAL LLC • Houston, TX

50d • Onsite

About The Position

We’re seeking an Internal Medicine physician to serve as a Principal Investigator (PI) at our Houston, TX research site. This position is ideal for a physician seeking a slower pace of work and very flexible, part-time hours (approximately 10–20 hours/week; typically 10–25 hours/week depending on study needs). Comprehensive PI onboarding and ongoing support are provided. You’ll provide medical oversight for clinical trials, ensure participant safety, and help generate high-quality data—without the heavy demands of a traditional clinic schedule.

Requirements

• MD or DO (Internal Medicine).
• Active, unrestricted Texas Medical Board license.
• Interest in clinical research and comfort reviewing structured clinical data.
• Strong documentation, communication, and confidentiality practices (HIPAA/PHI).

Nice To Haves

• Prior experience as a PI or Sub-Investigator (training provided for the right candidate).
• Familiarity with ICH-GCP and FDA regulations (21 CFR Parts 50, 54, 56, 312, 812).
• Board certification in Internal Medicine; DEA registration if required by specific protocols.

Responsibilities

• Serve as the study physician for assigned trials; ensure participant safety and ethical conduct.
• Review and confirm participant eligibility; oversee screening outcomes, AEs/SAEs, and retention trends.
• Perform/oversee study-specific medical assessments (histories/physicals, concomitant meds, endpoint review).
• Provide medical oversight to site staff (Sub-Investigators, CRCs, RNs, lab staff); be available for consults and safety questions.
• Collaborate with IRBs, sponsors, and CROs; join SIVs, monitoring visits, and close-out activities as needed.
• Ensure compliance with protocols, site SOPs, ICH-GCP, FDA/21 CFR, and  (enter name of State here) state requirements.
• Review clinical data (labs, ECGs, vitals) and support timely safety reporting and documentation.
• Contribute to high-quality source documentation, query resolution, and continuous improvement of site processes.

What This Job Offers

• Job Type: Part-time
• Education Level: Ph.D. or professional degree