Principal Investigator, Pediatric Oncology Research Laboratory

American Addiction Centers•Charlotte, NC

49d•Onsite

About The Position

Atrium Health Levine Children’s is initiating a search for an accomplished physician scientist (MD or MD/PhD) specializing in pediatric sarcoma research and treatment. The successful candidate will lead the Pediatric Oncology Research Laboratory (PORL), focusing on advancing new therapies for pediatric sarcoma patients. This role requires both a strong research background and includes limited clinical duties, offering a unique opportunity to impact patient care and translational science. Established in 2020 at Cannon Research Center, the PORL provides a modern and collaborative environment for pediatric cancer research. The lab is equipped with advanced technology, including a Helios Mass Cytometer (CyTOF), supporting innovative studies in tumor immune microenvironment, tumor heterogeneity, stem cell biology, and immunotherapy. Additional resources include IVIS in vivo imaging, Incucyte S3 real-time cell imager, and full cell culture and western blot capabilities. The Pediatric Cancer and Blood Disorders program at Atrium Health Levine Children’s in Charlotte, NC is recruiting an established physician scientist (MD or MD/PhD) for the Isabella Santos Foundation (ISF) Endowed Professorship for Pediatric Cancer Research. Three to five years initial full salary and basic/translational research support are available for an experienced researcher to advance new therapies for pediatric sarcoma patients. The incumbent will lead the Levine Children’s Pediatric Oncology Research Laboratory (PORL) and will represent the department as a member of the NCI-designated Atrium Health Wake Forest Baptist Comprehensive Cancer Center (WFBCCC) and as a faculty member of the Wake Forest School of Medicine (WFSM) (at the Associate or Full Professor levels). The PORL is particularly well equipped to advance basic/translational studies of pediatric sarcoma tumor immune microenvironments, tumor heterogeneity / stem cell biology, and immunotherapy. The PORL has a dedicated Helios Mass Cytometer (CyTOF) and experienced CyTOF staff, IVIS in vivo imaging system and affiliated in-building vivarium facilities, Incucyte S3 real-time cell imager, and full cell culture facilities. The Levine Children’s PORL hosts a pediatric sarcoma biospecimen repository and staff are experienced in multi-center biobanking efforts. Levine Children’s is the headquarters for the ARISE Consortium, which unites pediatric oncology programs from across North and South Carolina, and is a full member of the Sunshine Consortium, the PTCTC, and other national clinical trial consortia that focus on pediatric sarcoma treatment and immunotherapy, offering multiple unique opportunities for translational research efforts in pediatric sarcoma. The ISF Endowed Professor for Pediatric Cancer Research will join the Wake Forest School of Medicine faculty as well as the Atrium Health Wake Forest Baptist Comprehensive Cancer Center and a vast institutional collaborative network including investigators with expertise in immunology, drug design, and genomics. The AHWFBCCC basic/translational research program is home to a world-class clinical trials program as well as several sophisticated core facilities with specialties including molecular biology, flow cytometry, proteomics/metabolomics, bioinformatics, biostatistics, and comparative medicine (vivarium). With fifteen physicians, the faculty of the Pediatric Cancer and Blood Disorders program at Levine Children’s represents the largest pediatric hematology/oncology division (and the only pediatric stem cell transplant / cellular therapy program) serving the six million people who live in Charlotte, Winston-Salem, western North Carolina and northern South Carolina. The Cancer and Blood Disorders program at Levine Children’s sees over 175 new diagnoses annually and includes active pediatric stem cell transplant, cellular therapy (CAR-T and NK), gene therapy, proton therapy, and Phase I programs. Charlotte NC, home of the 4-year Wake Forest School of Medicine – Charlotte program, is among the fastest growing large cities in America and is repeatedly ranked among “Best Places to Live” surveys. Successful candidates will have an established independent research program with a demonstrated record of productivity in research, extramural funding (especially NCI), and clinical trials. Investigators in the specific areas of tumor immune microenvironments, tumor immunology, or immunotherapy are especially encouraged to apply.

Requirements

MD or MD/PhD board certified / eligible in Pediatric Hematology/Oncology
Established record of productivity in research, extramural funding (especially NCI), and clinical trials.

Nice To Haves

Expertise in tumor immune microenvironments, immunology, or immunotherapy is highly desirable.
Experience in pediatric sarcoma research preferred.

Responsibilities

Lead and expand an independent research program in pediatric sarcoma.
Collaborate with a robust network of basic/translational investigators and clinical trial consortia.
Conduct limited clinical duties as part of the pediatric Cancer and Blood Disorders program.
Utilize state-of-the-art lab resources, including CyTOF, IVIS imaging, and cell culture facilities.

Benefits

Advocate Health offers a comprehensive suite of Total Rewards: benefits and well-being programs, competitive compensation, generous retirement offerings, programs that invest in your career development and so much more – so you can live fully at and away from work, including:
Compensation Base compensation listed within the listed pay range based on factors such as qualifications, skills, relevant experience, and/or training Premium pay such as shift, on call, and more based on a teammate's job Incentive pay for select positions Opportunity for annual increases based on performance
Benefits and more Paid Time Off programs Health and welfare benefits such as medical, dental, vision, life, and Short- and Long-Term Disability Flexible Spending Accounts for eligible health care and dependent care expenses Family benefits such as adoption assistance and paid parental leave Defined contribution retirement plans with employer match and other financial wellness programs Educational Assistance Program

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