Principal Downstream Scientist – mRNA purification

GSK•Cambridge, MA

2d•$115,500 - $192,500

About The Position

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people’s lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients’ needs and have the highest probability of success. We’re uniting science, technology, and talent to get ahead of disease together. Find out more: Our approach to R&D Are you ready to make a meaningful impact in the development of mRNA-based vaccines? As a Principal Downstream Scientist specializing in mRNA purification, you will play a key role in advancing innovative vaccine platforms. You will design and optimize purification processes, collaborate with cross-functional teams, and contribute to the development of scalable solutions. We value candidates who are driven, collaborative, and eager to bring fresh ideas to the table. This role is based in the United States and offers an exciting opportunity to work at the forefront of vaccine development.

Requirements

Master’s or PhD. degree in Molecular Biology, Biotechnology, Bioengineering, Chemical Engineering, or a related field.
Five years (Master's) or Three years (PhD.) of industry experience in downstream process development for large biomolecules, including mRNA or pDNA.
Three or more years of experience with purification techniques such as affinity capture, ion exchange, and hydrophobic interactions.
Three or more years of experience supporting CMC activities, including process and analytical development.

Nice To Haves

PhD in Molecular Biology, Biotechnology, Bioengineering, Chemical Engineering, or a related field.
Experience with Quality by Design principles and DOE studies for process optimization.
Knowledge of regulatory guidelines (FDA/ICH/ISPE) for process validation and technology transfer.
Familiarity with nucleic acid analytical technologies.
Strong problem-solving skills and ability to work collaboratively in a matrixed environment.

Responsibilities

Design, execute, and analyze experiments to develop and optimize mRNA purification processes.
Ensure processes are scalable and phase-appropriate for clinical manufacturing.
Collaborate with global teams, including analytical R&D, GMP, and process development colleagues.
Drive innovative solutions to improve purification techniques and meet project milestones.
Stay current with industry trends and emerging technologies in downstream processing.
Maintain detailed documentation to ensure data integrity and compliance.