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The Principal Biostatistician may function independently as a statistical consultant/project manager by applying statistical, programming, and related methods such as machine learning and scientific expertise to the design, implementation, analysis, interpretation, and reporting of research, clinical and administrative studies. The Principal Biostatistician must possess advanced level expertise in a wide variety of statistical techniques and other skills listed for Biostatistician, to meet the demands of study teams and investigators. The Principal Biostatistician must possess advanced knowledge of biology and medicine and be able to identify and apply analytical approaches as they relate to these fields. The Principal Biostatistician will direct development of case report forms (CRFs) and/or databases as well as monitor the progress for most biostatistical aspects of research and clinical studies. The Principal Biostatistician will delegate tasks to statistical programmers, Biostatisticians, and other study personnel for most studies. The Principal Biostatistician will summarize and communicate project findings to study team members, investigators, journal and grant reviewers, committees, and other individuals and entities as needed. The Principal Biostatistician will contribute significantly to grant and report writing, scientific publications and/or regulatory reports. The Principal Biostatistician functions as the primary statistician on most studies.