Postdoctoral Scholar - Pediatrics

Penn State University • University Park, PA

126d

About The Position

The Department of Pediatric Hematology/Oncology at Penn State Hershey College of Medicine, in Hershey, PA, is currently accepting applications for a postdoctoral scholar. The lab focuses on delineating the epigenetic pathways that regulate normal hematopoiesis and to further determine how regulatory networks are perturbed in leukemia. Our current research focuses are: 1) Investigating the underlying molecular mechanisms by which 3D genome topology controls the hematopoietic transcription program and lineage differentiation in normal and malignant hematopoiesis. 2) Delineating the role of long noncoding RNAs in regulating CTCF boundary function during hematopoiesis and leukemogenesis. 3) Epigenetic and transcriptional regulation of hematopoietic stem cell function. We utilize a variety of approaches including biochemical, proteomic, genomic, genome editing, and mouse modeling to study these questions. Here are representative recent publications from the lab (Luo et al., Blood, 2018, 132 (8): 837-848; Luo et al., 2019, Cancer Cell, 36: 645-659; Zeisig et al., Science Translational Medicine, 2021, 13 (482): eabc4822; Zhu et al., Nature Communications, 2021, 12 (1): 1956. Doi: 10.1038/s41467-021-22095-2); Li et al., 2020. NAR, 48(6): 3119-3133.

Requirements

• PhD or MD/PhD degree in molecular biology, biochemistry, bioinformatics, mouse genetics or a related field.
• Evidence of prior productive scientific work in the form of publications in peer-reviewed journals.

Nice To Haves

• Prior experience in the study of gene regulation.
• Experience in hematopoiesis.
• Use of mouse models.

What This Job Offers

• Industry: Educational Services
• Education Level: Ph.D. or professional degree