Postdoctoral Scholar - Biochemistry and Molecular Biology

Penn State University • University Park, PA

110d

About The Position

One Postdoctoral Position is available in the lab of Dr. Manyu Du at The Pennsylvania State University. The Du lab is interested in understanding how transcription machineries and regulatory DNA elements organize in 3D in the nucleus to regulate gene expression. We leverage single-molecule super-resolution imaging, advanced lattice light sheet microscopy and other state of the art biophysical approaches to study molecular mechanisms of transcription, genome organization and bio-molecular condensation in live cells. We are using mouse embryonic stem cells and mouse erythroid leukemia cells to investigate the dynamics and function of transcriptional condensates in health and disease. Other than imaging, we are also interested in biochemical, genetic and sequencing approaches to understand gene regulation. This position is open immediately and initially funded for two years.

Requirements

• PhD in molecular biophysics, biochemistry or a related discipline.
• Familiarity with studying bio-molecular condensates using biochemistry, fluorescence and quantitative modeling methods.
• Experience in single-molecule imaging and DNA/RNA imaging in live mammalian cells.
• Ability to work effectively in a team and possess good communication skills.

Responsibilities

• Investigate the behavior of individual molecules and bio-molecular condensates in living cells.
• Use and develop imaging and computational methods to visualize dynamic molecule clusters during gene expression.
• Study the formation and function of molecular assemblies in gene regulation.

Benefits

• Term appointment initially funded for two years with possibility of refunding.

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Industry: Educational Services
• Education Level: Ph.D. or professional degree