Postdoctoral Research Fellow - T Cell Engineering Lab

Mayo Clinic • Rochester, MN

4d

About The Position

The T Cell Engineering Laboratory (Kenderian Laboratory) at Mayo Clinic is
seeking a highly motivated and talented Postdoctoral Research Fellow to lead and
contribute to the development of next-generation engineered cell therapies for
cancer and immune-mediated diseases.

Our laboratory is recognized for its work in CAR T cell biology, synthetic and
logic-gated cell therapies, mechanisms of resistance and toxicity, and
translational immunotherapy, with a strong emphasis on moving discoveries from
bench to clinic. The successful candidate will work in a highly collaborative,
well-resourced environment with direct access to GMP manufacturing, clinical
trials, and multidisciplinary translational teams.

This position is ideal for individuals aspiring to careers in academic medicine,
biotechnology, or translational research leadership. The postdoctoral fellow
will have the opportunity to lead independent and collaborative projects in
areas including (but not limited to):

Design and engineering of next-generation CAR T and other engineered immune
cell therapies
Synthetic biology approaches (e.g., logic-gated receptors, synNotch, armored
CARs)
Overcoming tumor immune evasion, antigen loss, exhaustion, and senescence
Mechanisms of on-target/off-tumor toxicity and immune-related adverse events
Translational studies bridging preclinical models, GMP manufacturing, and
early-phase clinical trials
Solid and hematologic malignancies, with opportunities for cross-platform
innovation

Projects will be tailored to the fellow’s expertise and career goals, with
strong encouragement and support for first-author high-impact publications and
independent funding applications. The laboratory offers a unique translational
ecosystem, including:

State-of-the-art BSL-2+/cell engineering laboratories
Access to GMP cell manufacturing through the Center for Regenerative
Biotherapeutics
Close interaction with clinician-scientists, immunologists, bioengineers, and
industry collaborators

Strong mentoring culture with structured guidance in:

Grant writing (NIH K99/R00, foundation awards)
Manuscript preparation for top-tier journals
Scientific presentation and leadership development
Career advancement in academia or industry

Responsibilities

• Design and engineering of next-generation CAR T and other engineered immune cell therapies
• Synthetic biology approaches (e.g., logic-gated receptors, synNotch, armored CARs)
• Overcoming tumor immune evasion, antigen loss, exhaustion, and senescence
• Mechanisms of on-target/off-tumor toxicity and immune-related adverse events
• Translational studies bridging preclinical models, GMP manufacturing, and early-phase clinical trials
• Solid and hematologic malignancies, with opportunities for cross-platform innovation

Benefits

• Medical: Multiple plan options.
• Dental: Delta Dental or reimbursement account for flexible coverage.
• Vision: Affordable plan with national network.
• Pre-Tax Savings: HSA and FSAs for eligible expenses.
• Retirement: Competitive retirement package to secure your future.

What This Job Offers

• Job Type: Full-time
• Education Level: No Education Listed
• Number of Employees: 5,001-10,000 employees