The University of Virginia (UVA) seeks a Postdoctoral Research Associate position in the laboratory of Bon Trinh. Ph.D., Tenure-track Assistant Professor of Pathology and UVA Comprehensive Cancer Center. The broad areas of interest in Dr. Trinh's lab include: gene regulation by RNAs and proteins, modulation of gene-specific chromatin architecture, blood development, cancer and genetic diseases, therapeutic development. His lab employs a multidisciplinary approach, comprising biochemistry and cellular biology as well as global transcriptomic, epigenomic, and 3D chromatin structure analyses, using normal and cancer cells, and mouse models. Research in the Trinh lab centers on protein- and RNA- mediated gene regulation via modulating chromatin architecture in development of immune cells, particularly myeloid cells, a critical component of the body defense against infections, and how abnormalities in this regulation contribute to failure in myeloid cell maturation resulting in acute myeloid leukemia. The lab also investigates this molecular coordination in drug resistance and immune cell-cancer cell communications within the tumor microenvironment. The aims are to provide critical mechanistic insights into normal and malignant hematopoiesis, and to establish certain protein-RNA hubs as actionable therapeutic targets and molecular markers, contributing to the emerging field of precision medicine. The successful candidate will join an interdisciplinary research group in which research questions and novel ideas are valued and examined from experimental and computational angles. The candidate will have opportunities to drive his/her own research project(s), develop fellowship applications, write manuscripts, mentor junior trainees, and learn skills of interest along the way.
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Job Type
Full-time
Career Level
Entry Level
Industry
Hospitals
Education Level
Ph.D. or professional degree