Postdoctoral Research Associate - Cardiology
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About The Position
The Shen Lab within the Division of Cardiology and Department of Medicine at WashU Medicine in St. Louis, USA is recruiting two postdoctoral associates. Our lab specializes in precision cardiovascular medicine, leveraging cutting-edge approaches such as human iPSC-derived 2D cardiovascular cells, 3D vascularized cardioids, CRISPR gene editing, high-throughput CRISPRko/i/a screening, single-cell multiomics, tissue engineering, and animal models. Our current research primarily focuses on four key areas: 1) Developing robust, chemically defined differentiation protocols to generate diverse cardiovascular cell types from iPSCs, enabling advanced cardiovascular disease modeling and cell therapy applications, 2) Uncovering genetic drivers of anti-cancer drug-induced cardiovascular toxicity through integrated iPSC models and high-throughput CRISPRi/a screening, 3) Deciphering pathogenic coding and non-coding variants linked to congenital heart disease in a cell type-specific manner, and 4) Combining iPSC-derived cells and single-cell perturb sequencing to establish foundational models to predict the effects of potential drug candidates on cardiovascular diseases. By combining genome engineering, functional genomics, and tissue models, we aim to advance mechanistic insights and therapeutic strategies for cardiovascular diseases. We are seeking highly motivated, creative postdoctoral fellows to drive innovations in cardiovascular precision medicine. We welcome candidates with expertise in iPSC biology, functional genomics, developmental biology, cardiovascular disease, and/or bioinformatics to explore the intersection of cardiovascular physiology, cancer biology, and regenerative medicine. This position offers the opportunity to develop translational research projects using cutting-edge approaches in a dynamic, interdisciplinary environment. Our lab provides a collaborative and supportive culture that champions teamwork, scientific curiosity, and innovation. Successful candidates will lead impactful research initiatives while receiving personalized mentorship to foster their growth as independent investigators. We are committed to your career success, offering dedicated support for fellowship applications, training grants, and transition to independence, along with opportunities to develop leadership and mentoring skills. WashU offers outstanding research infrastructure and professional development resources through its Career Center, Teaching Center, and Office of Postdoctoral Affairs. As part of our vibrant scientific community, you will have access to state-of-the-art facilities and a network of interdisciplinary collaborators.
