Postdoctoral Fellow

Mass General Brigham • Belmont, MA

1d • Onsite

About The Position

We are seeking a highly motivated Postdoctoral Fellow to join our research program focused on the role of regulatory T cells (Tregs) in improving outcomes in cell replacement therapy for neurodegenerative disease. The successful candidate will lead studies aimed at defining how Tregs modulate immune responses associated with transplantation and how they may enhance graft survival and function. The postdoctoral fellow will investigate the immunosuppressive activity of Tregs, including their capacity to regulate host inflammatory responses before and after transplantation. A major emphasis of the project will be to understand the mechanisms that influence Treg survival, persistence, and function post-transplantation. The fellow will also study approaches to mitigate the pro-inflammatory response associated with needle trauma, a key barrier to successful cell delivery and engraftment. In addition, the candidate will explore the biology of local brain-resident or tissue-localized Tregs and their role in limiting neuroinflammation within the transplant microenvironment. This work will integrate cellular immunology, transplantation biology, and neuroinflammation, with the goal of developing strategies that improve the safety and efficacy of regenerative therapies in the central nervous system. The ideal candidate should have a strong background in immunology, neuroimmunology, stem cell biology, transplantation biology, or a related biomedical field. Candidates should be independent, scientifically rigorous, and enthusiastic about working in an interdisciplinary and translational research environment. This position offers the opportunity to contribute to a growing area of investigation at the interface of immunology, neuroscience, and regenerative medicine, with strong potential for high-impact publications and translational relevance. The Postdoctoral Fellow will lead research efforts aimed at defining the role of regulatory T cells in cell replacement therapy, with particular emphasis on transplantation-associated inflammation and graft protection. Research activities will include evaluating the immunosuppressive properties of Tregs, determining their survival and persistence following transplantation, and identifying mechanisms to reduce the pro-inflammatory response associated with needle trauma during cell delivery. The fellow will also investigate the role of local Tregs in the brain and their contribution to the control of local inflammation within the transplant environment.

Requirements

• Strong background in immunology, neuroimmunology, stem cell biology, transplantation biology, or a related biomedical field.
• Independent.
• Scientifically rigorous.
• Enthusiastic about working in an interdisciplinary and translational research environment.

Nice To Haves

• Experience with T-cell biology.
• Experience with flow cytometry.
• Experience with in vitro immune assays.
• Experience with animal models.
• Experience with histology.
• Experience with molecular or cellular techniques.

Responsibilities

• Lead studies aimed at defining how regulatory T cells (Tregs) modulate immune responses associated with transplantation and how they may enhance graft survival and function.
• Investigate the immunosuppressive activity of Tregs, including their capacity to regulate host inflammatory responses before and after transplantation.
• Understand the mechanisms that influence Treg survival, persistence, and function post-transplantation.
• Study approaches to mitigate the pro-inflammatory response associated with needle trauma, a key barrier to successful cell delivery and engraftment.
• Explore the biology of local brain-resident or tissue-localized Tregs and their role in limiting neuroinflammation within the transplant microenvironment.
• Lead research efforts aimed at defining the role of regulatory T cells in cell replacement therapy, with particular emphasis on transplantation-associated inflammation and graft protection.
• Evaluate the immunosuppressive properties of Tregs.
• Determine Treg survival and persistence following transplantation.
• Identify mechanisms to reduce the pro-inflammatory response associated with needle trauma during cell delivery.
• Investigate the role of local Tregs in the brain and their contribution to the control of local inflammation within the transplant environment.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree
• Number of Employees: 5,001-10,000 employees