At Pfizer, our purpose is to deliver breakthroughs that transform patients' lives. Central to this mission is our Research and Development team, which strives to convert advanced science and cutting-edge technologies into impactful therapies and vaccines. Whether you are engaged in discovery sciences, ensuring drug safety and efficacy, or supporting clinical trials, your role is crucial. You will leverage innovative design and process development capabilities to expedite the delivery of top-tier medicines to patients globally. We are looking for a highly motivated postdoctoral fellow with expertise in cell biology or biomedical engineering to join Pfizer's Pharmacokinetics, Dynamics and Metabolism (PDM) Department. In this position, the postdoctoral fellow will lead the advancement and validation of microfluidic-based in vitro tumor growth inhibition (TGI) models. With a focus on early prediction of effective concentrations and dosing, this project aims to significantly influence strategies to reduce and ultimately replace in vivo TGI studies. The successful candidate will be exposed to and collaborate with colleagues in oncology biology, proteomics, Translational Modeling and Simulation (TMS) and mass spectrometry. In this position, you will draw on your background in cell biology and your passion for developing advanced microfluidic in vitro systems to design tumor growth inhibition models for both solid and liquid tumors. You'll incorporate preclinical and clinical pharmacokinetic-pharmacodynamic (PK/PD) data to mimic relevant exposure profiles, will design the appropriate studies to monitor pharmacodynamic response, and work closely with TMS colleagues to establish and validate the correlation between in vitro and in vivo results (IVIVC). You will also present internally and externally and publish your results from this project.