Postdoctoral Fellow, Translational Medicine Oncology, Yadav Lab

Roche • South San Francisco, CA

10d • $100,000 - $106,500

About The Position

A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That’s what makes us Genentech. A Postdoctoral fellow position is available for a highly motivated and independent candidate to join the laboratory of Dr. Mahesh Yadav in the Translational Medicine Oncology department at Genentech. Dr. Yadav’s lab focuses on understanding and monitoring anti-tumor specific T cell responses to track treatment outcomes and inform clinical decisions, and discovering novel tumor antigens for cancer vaccines. This position will focus on mapping the repertoire of T cell receptors (TCRs) against tumor antigens and using this as a tool to identify and validate various classes of tumor antigens. It will also involve using advanced technologies such as single-cell sequencing (CITE-seq) and spatial transcriptomics on clinical specimens for monitoring T cell responses. This postdoctoral position will provide an opportunity to contribute to the exciting cancer vaccine pipeline in gRED. Candidates familiar with T cell immunology, TCR sequencing, and computational analysis are especially encouraged to apply. The Opportunity: Discovery and Research: Identification and mapping of antigen-specific T cells/TCRs to track longitudinal T cell dynamics Computational Workflow: TCR sequencing on clinical samples followed by computational analysis for identifying predictive and pharmacodynamic biomarkers Collaborative Research: You will have opportunities to productively collaborate with other researchers across departments, present your work to project teams, and contribute to high-impact scientific publications. Strategic Impact: As a member of the Translational Medicine Oncology department, you will join leaders in leading projects that align with Genentech’s cancer vaccine strategic efforts. Professional Development: You will be part of the Genentech post-doctoral training program, which provides an outstanding environment and the opportunity to pursue fundamental basic science questions while utilizing clinical trial samples to drive breakthrough discoveries in drug development.

Requirements

• Ph.D. with a proven track record of excellence in immunology and/or cellular/ molecular biology with experience in data analysis
• Must have advanced at least one key research project as evidenced by a first author paper published or accepted in a leading peer-reviewed journal.
• Independent scientist with outstanding communication skills, a strong passion and commitment to science and immunology, who works well within a team
• Excited about identifying novel targets for treatment of cancer

Nice To Haves

• Hands-on experience in immunology/cancer immunology studies is highly desired
• Track record of successfully conducting laboratory experiments
• Working knowledge of bioinformatics tools is a plus.

Responsibilities

• Identification and mapping of antigen-specific T cells/TCRs to track longitudinal T cell dynamics
• TCR sequencing on clinical samples followed by computational analysis for identifying predictive and pharmacodynamic biomarkers
• Collaborate with other researchers across departments
• Present work to project teams
• Contribute to high-impact scientific publications

Benefits

• competitive salaries
• fully funded research expenses
• access to world-class seminars
• professional development workshops
• networking opportunities
• Relocation benefits are available for this job posting.

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree