Postdoctoral Fellow in Allergy and Immunology

Mass General Brigham • Boston, MA

1d • Onsite

About The Position

The Patil laboratory in the in the Center for Immunology and Inflammatory Diseases (CIID) at Massachusetts General Hospital and Harvard Medical School is seeking a highly motivated postdoctoral fellow to study allergen-specific B cells in the development and treatment of allergic diseases. My laboratory seeks to understand how allergies develop and how they can be effectively treated by understanding the role of antibodies in allergy and tolerance. Our translational research approach leverages the application of cutting edge, sample sparing techniques to understand clinical manifestations of disease. To that end, we have pioneered the application of fluorescent multimers to identify rare, allergen-specific B cells, combined with single cell B cell receptor sequencing, to structurally characterize of antibodies and their antigenic targets on a subatomic level. Our work has led to the identification of neutralizing antibodies and their role in sustained responses after oral immunotherapy, as well as the identification of convergent, or public antibodies. From this work, we have a clearer insight into antibodies from individuals but also on a population level. We are seeking a highly motivated PhD, MD/PhD, or MD scientist with a background in molecular biology with an interest in bioinformatics to lead translational research in food allergy. and translating these discoveries into new therapeutic strategies. In order to understand the role of allergen-specific B cells in the development of food allergies and treatment, the candidate will engage in cutting-edge technologies, unifying allergen-specific B cell studies with transcriptomics, proteomics, and functional assays to discover novel therapies for food allergy. Individual projects will be tailored to the candidate’s background and interests.

Requirements

• The ideal candidate has a strong background and experimental immune phenotyping, mammalian cell culture, and a broad range of molecular and cellular biology techniques, including genomics approaches.
• A strong ability to work independently and in a team, troubleshoot experimental challenges, and maintain attention to detail is valued as are analytical, organizational, and communication skills.
• A documented track record of significant prior scientific achievement in the field of immunology is encouraged.

What This Job Offers

• Education Level: Ph.D. or professional degree
• Number of Employees: 5,001-10,000 employees