Postdoctoral Fellow, Immunology
About The Position
We are seeking a highly motivated and highly productive Postdoctoral Fellow to contribute to advancing targeted RNA-therapeutics delivery to immune cells. This role offers a unique opportunity to gain deep research experience in a fast-paced industry environment while making a meaningful contribution to the development of next-generation RNA medicines. The successful candidate will explore and validate receptor-based delivery strategies on immune cell subsets to enable efficient uptake of diverse RNA-targeted modalities. The project integrates computational profiling, ligand screening, in vitro and in vivo validation strategies to overcome delivery challenges and establish compelling proof-of-concept data. This position provides a rare chance to shape innovative therapeutic approaches, generate patentable and publishable discoveries, and work at the intersection of cutting-edge science and real-world drug development.
Requirements
- Ph.D. in Immunology, Molecular Biology, Cell Biology, or related fields with 0-3 years of postgraduate training
- Familiarity with flow cytometry, including panel design and data analysis
- Experience with cell culture techniques, including primary immune cell isolation and maintenance
- In vivo study experience or willingness to learn
- Experience with molecular biology methods (e.g., RNA analysis, qPCR, siRNA/ASO delivery)
- Strong written and verbal communication skills for publication and presentation
- Required to be full-time onsite at Carlsbad, CA
Nice To Haves
- Strong background in immunology and lymphocyte biology is a plus
- Ability to analyze large datasets (e.g., scRNA-seq, transcriptomics) and interpret receptor expression profiles is a plus
- Excellent problem-solving skills and ability to design experiments independently
Responsibilities
- Identify and prioritize cell-surface receptors relevant to immune-cell biology, applying scientific creativity and critical thinking to advance delivery strategies.
- Validate receptor expression and function using advanced analytical approaches, including flow cytometry, single-cell profiling, and RNA-seq.
- Design and execute in vitro and in vivo studies to evaluate target knockdown, delivery efficiency, and cell-type specificity, exercising sound judgment within established procedures.
- Analyze and interpret complex datasets to guide decision-making, review key technical factors, and shape project strategy.
- Document experimental results and communicate clear, concise findings through regular internal presentations, writing manuscripts for scientific publications, and contributions to posters.
- Collaborate effectively with cross-functional teams and external partners, building alignment around technical decisions and contributing to collective problem-solving.
- Contribute to innovation and intellectual property development through rigorous experimentation and documentation.
- Demonstrate professionalism and uphold the company's culture, core principles, and collaborative working norms.
Benefits
- Ionis offers an excellent benefits package!
- Full Benefits Link: https://www.ionis.com/careers/working-at-ionis/#:~:text=our%20employee%20spotlight-,Benefits,-Employees%20are%20rewarded
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What This Job Offers
Job Type
Full-time
Career Level
Entry Level
Industry
Chemical Manufacturing
Education Level
Ph.D. or professional degree
Number of Employees
1,001-5,000 employees
