We are seeking a highly motivated Postdoctoral Associate. Ideal candidate will lead their own project, and perform mammalian cell culture, in vivo mouse experiments, in vivo genetic screens, quantitative TMT mass spectrometry proteomics, metabolomics, western blot, pulldowns, DNA cloning, immunostaining, confocal microscopy, high throughput screens, and bioinformatic data analysis. Significant emphasis is placed on the professional development of the Postdoctoral Associate. More information on the project will be discussed during the interview process. Lab Project Overview: To maintain homeostasis, organisms rely on internal signaling networks that orchestrate the physiological response across different tissues and organs. Intriguingly, perturbation in one tissue elicits secreted signals that transmit the information to other tissues and that these signals are important for maintenance of health and longevity. Secreted proteins are key components of interorgan signaling that coordinate organ functions by signaling over long distances. Destabilization of these interorgan signaling networks, responsible for the orchestration of physiological responses across organs, drives age-associated disease, including diabetes, cancer, or chronic inflammation. Despite this, the composition and activity of interorgan communication networks and their impact on aging and disease remain poorly defined. The Droujinine Lab has developed novel methods to identify and characterize novel secreted factors that coordinate organ functions in homeostasis and disease in mammalian systems. Specifically, we use proteomics and in vivo functional genomic screens to uncover the secreted proteins and cellular circuitry involved in homeostasis, obesity, and aging. To learn more please visit www.scripps.edu/droujinine