Postdoctoral Associate | Laboratory of Molecular Biology
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About The Position
The Laboratory of Molecular Biology at The Rockefeller University is seeking a highly motivated and outstanding candidate for an exciting postdoctoral position to study the selective vulnerability and degeneration of upper motor neurons in amyotrophic lateral sclerosis (ALS). ALS presents a paradox in that most known disease-causing mutations are ubiquitously expressed, yet only discrete populations of cells degenerate. We therefore use a multidisciplinary approach, centered on advanced molecular profiling methods to elucidate cell type-specific phenotypes during disease progression in preclinical mouse models and postmortem human tissue. By contrasting vulnerable and resilient neuronal populations as well as non-neuronal cells, we hope to identify novel disease mechanisms and putative entry points for therapeutic intervention. These studies are integrated with modern anatomical and circuit-tracing methods and bioenergetics to map the identity, connectivity, and function of neuronal cell types in cortical and motor circuits.
