POSTDOCTORAL ASSOCIATE -Postdoctoral Associate, Cell Biology & Chemical Biology

The Scripps Research Institute • San Diego, CA

71d • Onsite

About The Position

The candidate will join an early-stage discovery research group at Calibr-Skaggs. Under guidance and in collaboration with others the candidate will perform research in the areas of cell biology and chemical biology. Specifically, the candidate will work on hit-to-lead drug discovery of small molecule and peptide drug candidates discovered through Calibr-Skaggs' DNA-encoded library (DEL) platform. The primary goal of the research is to discover novel therapies for immunology and inflammation. The drug discovery pipeline at Calibr-Skaggs spans early discovery to IND, and the candidate will be engaged throughout this process. A successful candidate will be self-led and able to work both independently and collaboratively to lead research projects, analyze data and interpret results. The right candidate will be adaptable with a willingness to collaborate with others on a wide range of projects, and enthusiastically learn new skills/techniques.

Requirements

• Requires a PhD in cell biology, chemical biology, or related area or an equivalent combination of education and training.
• A strong track record of research productivity
• Highly motivated, creative, and devoted to project goals
• Able to collaborate proficiently and communicate effectively with colleagues and management teams
• Able to contribute in a meaningful way to scientific discourse
• Core knowledge of mammalian cell biology and chemical biology
• Experience with western blots, ELISA and/or AlphaLISAs
• Experience with PBMCs and other immunologically relevant cell types
• Experience with tissue culture, cell transfection and transduction
• Experience in drug discovery and an understanding of drug-protein interactions
• Experience in cell-based fluorescence imaging and flow cytometry

Nice To Haves

• Specific knowledge in Immunology and Inflammation
• Prior work with animal models
• Prior work with peptide drugs
• Prior work with DNA-encoded libraries

Responsibilities

• Work within discovery project teams and with scientists across different functional areas and be expected to present her or his work at project team meetings and to research leadership
• Work independently to design, execute, analyze, interpret and troubleshoot scientific experiments in cell and chemical biology
• Accurately maintain written reports and present results in an organized and timely manner to research leadership
• Communicate effectively with peers and supervisors, foster teamwork and contribute to collaborative efforts
• Strong commitment to quality in research and presentation
• Develop and implement robust cellular assays to support discovery of small molecules as clinical development candidates
• Design and execute research strategies that further our understanding of the mechanisms of novel compounds and targets
• Responsibilities include utilizing disease models to design target validation studies and relevant assays in support of SAR chemistry, mechanism of action, biomarker selection, and disease positioning

Benefits

• Eligibility for retirement plans with employer contribution.
• Full suite of Health and Welfare plans including three medical plan options (including an HSA available option), dental, vision, life insurance, disability, EAP and more.
• Access to Flexible Spending Accounts (Medical/Dependent Care).
• Free, on-site Counseling Center which provides confidential counseling services to benefits-eligible employees and their family members.
• Competitive vacation and sick leave policies.
• Free, on-site parking.
• Pet Insurance

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Industry: Educational Services
• Education Level: Ph.D. or professional degree
• Number of Employees: 1,001-5,000 employees