Post-Doctoral Fellows - Xu Lab
About The Position
The laboratory of Dr. Jianliang Xu in the HIV Cure and Viral Diseases Center at The Wistar Institute has two openings for Post-Doctoral Fellows to join. The Xu lab is interested in building nanobody discovery platforms and developing nanobody countermeasures against viral infections. Ongoing research focuses on developing broad and potent neutralizing nanobodies against various viral targets, including but not limited to HIV-1, henipavirus (HNV), arenavirus (ARV), herpesvirus (HSV), human metapneumovirus (HMPV), and respiratory syncytial virus (RSV). We are also working on nanobody therapeutics for melanoma and glioblastoma. We are seeking two highly motivated postdoctoral fellows to develop a high-throughput nanobody discovery and maturation system and apply the system for the identification and optimization of virus- or cancer-targeting nanobodies. Related publications include Nature (2021; PMID: 34098567); Advanced Science (2024; PMID: 38704686). The Wistar Institute is located in the University City area of Philadelphia, in the heart of the University of Pennsylvania Campus. Wistar provides resources for cutting-edge collaborative research and provides for outstanding intellectual environments and state-of-the-art facilities. The Wistar Institute is a world leader in early-stage discovery science in the areas of cancer, immunology, and infectious disease. The Institute is committed to accelerating research advances from bench to bedside through brilliant science and distinctive approaches to collaboration among scientific investigators and academic and industry partners. Wistar’s single-minded focus is on making discoveries that will change the future of human health. It is the policy of the Institute to provide equal employment opportunities to all individuals regardless of race, citizenship, ethnicity, color, creed, religion, marital status, national origin, ancestry, sex, age, veteran status, mental or physical disability (including HIV and AIDS), pregnancy, caregiver status, domestic or sexual violence victim status, sexual orientation, gender identity and expression, or on the basis of genetic information, or any other characteristic protected by federal, state, or local law, with respect to all terms and conditions of employment.
Requirements
- A strong background and publication record in virology and antibody discovery is essential.
- Candidates should have recently obtained, or be nearing completion of, a Ph.D. or equivalent degree.
Nice To Haves
- Expertise in yeast display technique, high-throughput pseudovirus neutralization screening system, and protein production and characterization is highly desired.
- Additional expertise in deep-sequencing library construction and data analysis, CAR T cells, and mouse models is highly valued.
Responsibilities
- develop a high-throughput nanobody discovery and maturation system
- apply the system for the identification and optimization of virus- or cancer-targeting nanobodies
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What This Job Offers
Career Level
Entry Level
Education Level
Ph.D. or professional degree
