Post-Doctoral Fellow

University of Colorado • Aurora, CO

1d • $62,232 - $75,564 • Onsite

About The Position

A Postdoctoral Associate position is available immediately in the laboratory of Elan Eisenmesser at the University of Colorado School of Medicine (Anschutz Medical Campus).
The Eisenmesser laboratory is located in a highly collaborative structural biology environment with access to:
Bruker 600 MHz and 900 MHz NMR spectrometers with cryoprobes
An on-site 200 kV Talos Arctica cryo-EM facility
Proteomics and metabolomics mass spectrometry cores
A comprehensive biophysics core facility
All major instrumentation is located in the same building.
Our group uses an integrative structural biology approach to understand how macromolecular structure and dynamics control function in systems relevant to infectious disease. We combine:
Solution NMR spectroscopy (structure, dynamics)
Cryo-EM of large macromolecular assemblies
Biochemistry and molecular biology
Current projects include:
Bacterial proteases that manipulate host pathways, with emphasis on conformational exchange and its role in enzyme mechanisms.
Macromolecular assemblies involved in microbial metabolism with a particular focus on protein-protein regulatory mechanisms.
The successful candidate will apply advanced NMR methods and develop cryo-EM expertise to study structure–dynamics–function relationships in these systems.

Requirements

• A Ph.D. in biochemistry, structural biology, biophysics, or a related field
• Strong experience in biomolecular NMR
• Strong written and verbal communication skills, including the ability to contribute to manuscripts and presentations
• Ability to lead and troubleshoot research projects
• Experience analyzing complex experimental or computational datasets and synthesizing results into clear conclusions
• Ability to mentor junior researchers and collaborate effectively within a multidisciplinary research environment
• Ability to manage multiple projects, meet research deadlines, and contribute positively to a rigorous and inclusive lab culture
• Expertise in protein expression and purification

Nice To Haves

• Experience with cryo-EM is welcome but not required.
• The position is ideal for candidates interested in expanding from NMR into integrative structural biology.
• We seek a highly motivated scientist interested in linking macromolecular dynamics to biological function in a collaborative and fast-paced environment.

Responsibilities

• Apply advanced NMR methods
• Develop cryo-EM expertise to study structure–dynamics–function relationships

Benefits

• The University of Colorado offers a comprehensive benefits package.
• To see what benefits are available for Post-Doctoral Fellows, please visit: · Payroll & Benefits Orientation for Post-Doctoral Fellows | University of Colorado (cu.edu) · Post-Doctoral Benefits Guide
• There are many additional perks & programs with the CU Advantage.
• The University of Colorado provides generous leave, health plans and retirement contributions that add to your bottom line.

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree