This job is no longer available
There are still lots of open positions. Let's find the one that's right for you.
We deliver 4.3 billion healthcare solutions to people every year, thanks to the flawless planning and meticulous eye for detail of our Manufacturing & Supply teams. With your talent and ambition, we can do even more to protect people from infectious diseases and bring hope to patients and their families. Sanofi's Global MSAT (Manufacturing Sciences, Analytics, and Technology) acts as a crucial link between our R&D and Manufacturing entities, playing an instrumental role in enhancing our current portfolio and delivering future launches of high-quality and innovative drugs and vaccines. Global MSAT is a beacon of innovation and process excellence in Manufacturing, this includes guiding the journey of new products from their launch to commercial success, being at the forefront of Data Sciences and Digitalization. Join a team of talented and passionate international experts, scientists, and project leaders dedicated to inventing, designing, industrializing, and implementing cutting-edge industrial chemical and biological processes, analytical methods, and process modeling to successfully launch 3 to 5 new products by year. The Post-doctoral / Scientist I position is part of the Upstream team in the Recombinant Drug Substance (DS) function within global MSAT and is based at the Mammalian Platform hub in Framingham, MA. The Recombinant DS function within global MSAT is the owner of Life Cycle Management (LCM) of DS processes. Implementation of second-generation processes is one of the top performance enablers for Sanofi's biologics manufacturing network and integral to LCM. We deliver innovative, robust, and cost-effective next generation processes. In recent years we have successfully established second-generation manufacturing mammalian processes with a continuous process platform. The function is responsible for tech transfer, process validation, dossier preparation, & PAI support to enable launch of new and LCM products. We are pursuing future innovations such as digital labs, factory of the future, and advanced-analytics-based process understanding and control. The Scientist in this role will provide expert development of hybrid models and technical support to: (1) predict and optimize mammalian cell culture process parameters for enhanced cell growth and metabolism control, and (2) improve recombinant protein expression while maintaining desired product quality attributes (e.g., glycosylation patterns) in perfusion or fed-batch cultures. The candidate will conduct internal studies and collaborate with academic institutions and internal teams on developing hybrid models composed of first principle-based models such as metabolic flux analysis or genome-scale models and data-driven models such as neural networks. Additionally, the candidate will integrate Raman spectroscopy technology with the Raman team into the hybrid model. This individual will work in a team environment, collaborating with various colleagues within and outside the organization to develop upstream cell culture processes using state-of-the-art upstream lab systems.
