Post-Doctoral Associate
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About The Position
The Alam lab uses a combination of biochemical and structural (Cryo-EM and X-ray crystallography) techniques to primarily study macromolecules and macromolecular complexes involved in membrane transport, homeostasis, and biogenesis, with a particular focus on pinpointing lipid/protein interactions in context of membrane protein function. Maintenance of membrane bilayer integrity and tight control over material transfer across cellular and organellar membranes is central to proper physiological functioning. Dysfunction of these systems lies at the heart of several devastating, often fatal pathologies ranging from rare inherited diseases such as Zellweger's syndrome and adrenoleukodystrophy (both stemming from peroxisomal dysfunction) to a range of neurodegenerative disorders, diabetes, and cancer. Focusing on structural and functional studies of membrane transport proteins, the Alam lab is fully outfitted for mammalian cell culture and optimization and large-scale protein expression and purification as well as biochemical analysis. Projects will enjoy fantastic access to a state-of-the-art in-house Cryo-EM facility featuring a Titan Krios microscope equipped with a Gatan KIII-Biocontinuum Direct electron detector/energy filter combination. The Hormel Institute also houses an equipment core including fluorescent microscopes as well as analytical ultracentrifugation, ITC and BIACORE instruments, along with shared common use high speed centrifuges and a range of other high-end microscopes. The core facilities are further supported by dedicated facility managers responsible for training, support, and usage of equipment.
