Post Doc Fellow, Rodriguez Lab, College of Medicine, Department of Molecular & Cellular Biosciences

University of Cincinnati • Cincinnati, OH

41d • Onsite

About The Position

A full-time Postdoctoral Fellow position is available in the Structural Dynamics of Transcription Lab (PI: Dr. JB Rodriguez-Molina) in the Department of Molecular and Cellular Biosciences at the University of Cincinnati College of Medicine. The Structural Dynamics of Transcription Lab investigates the molecular mechanisms of transcription termination and their regulation in health and disease, using an integrated structural biology workflow that combines biochemistry, genomics, and cryo-electron microscopy (cryo-EM). We are seeking a self-driven, ambitious, and creative scientist eager to explore fundamental questions in gene regulation and excited to work at the interface of structural biology, biochemistry, and functional genomics. Depending on interests and expertise, the successful candidate may lead one of two complementary projects: A biochemical and structural project involving protein purification, reconstitution of macromolecular complexes, in vitro functional assays, and cryo-EM. A cellular and systems-level project focusing on CRISPR-based genetic screens, flow cytometry, genomics, and proteomics. Both projects aim to uncover how transcription termination machinery integrates with broader regulatory networks and how its dysfunction contributes to disease. Candidates will have the opportunity to learn new techniques and contribute to an interdisciplinary, collaborative research environment. Training will be provided where needed. Our research is supported by state-of-the-art core facilities for cryo-EM, proteomics, genomics, and flow cytometry, as well as high-performance computing resources at the University of Cincinnati College of Medicine.

Requirements

• Ph.D. (or equivalent) in Biochemistry, Molecular Biology, Genetics, Biophysics, or a related field.
• In-depth knowledge of specialized field, process or discipline.
• May require experience with specialized software programs.
• At least three years of research experience in biochemistry, structural biology, molecular biology, or related disciplines.

Nice To Haves

• Research experience in genetics, next generation sequencing, bioinformatics, biophysics, physics, math and engineering may also be considered.

Responsibilities

• Drive the research project in collaboration with the PI and other team members.
• Design, execute, and analyze experiments; develop new approaches and hypotheses as appropriate.
• Prepare research summary reports, and present research findings in manuscripts, lab meetings, and scientific conferences.
• Contribute to grant proposals and collaborative efforts as opportunities arise.
• Stay abreast of developments in the field to maintain and enhance professional expertise.
• Mentor junior trainees and help maintain an open, supportive, and rigorous research environment.
• Play an active role in seeking career and research advice, both from the faculty supervisor and from other faculty members as well.
• Engage in professional development activities and career planning with mentorship from the PI.
• Contribute to lab maintenance, including equipment maintenance and ordering of supplies, as needed.
• Perform related duties based on departmental need. This job description can be changed at any time.

Benefits

• Comprehensive Tuition Remission
• UC provides tuition remission for you and your eligible dependents, covering tuition costs for nearly all undergraduate and graduate programs offered by the university.
• Robust Retirement Plans
• As a UC employee, you won't contribute to Social Security (except Medicare). Instead, you'll choose between state pension plans (OPERS, STRS) or an Alternative Retirement Plan (ARP), with UC contributing 14-18% of your salary based on position.
• Real Work-Life Balance
• UC prioritizes work-life balance with a generous time-off policy, including:
• Vacation and sick time
• 11 paid holidays and additional end-of-year paid time off (Winter Season Days)
• 6 weeks of paid parental leave for new parents
• Additional Benefits Include:
• Competitive salary based on experience
• Comprehensive health coverage (medical, dental, vision, prescription)
• Flexible spending accounts & wellness programs
• Professional development & mentorship opportunities

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Industry: Educational Services
• Education Level: Ph.D. or professional degree
• Number of Employees: 5,001-10,000 employees