PKPD Group Leader, Principal Scientist

Metrum Research Group•Boston, MA

About The Position

At Metrum Research Group, we are driven to improve health and defeat disease, especially where there are unmet needs. We work at the intersection of data, science, and technology to generate insights that transform biomedical decision making. We are seeking a Principal Scientist and Group Leader, PKPD Modeling and Simulation who is passionate about advancing model informed drug development and mentoring the next generation of scientists. If you are energized by scientific excellence, collaboration, and sharing knowledge openly with the community, we would love to connect. The Role This position combines scientific leadership, client engagement, and people development. You will lead a team of modeling and simulation scientists while also serving as a Project Leader on client engagements. You will shape pharmacometric strategy, guide quantitative decision making, and contribute to the broader scientific community through publication and presentation. This role may be hired at the Principal Scientist I or II level based on experience and demonstrated leadership impact. Why MetrumRG We believe our success depends on the well being and growth of our team. We are committed to creating a work life that is engaging, rewarding, and meaningful. Our culture values continuous learning, scientific rigor, collaboration, and open sharing of knowledge. We offer competitive compensation and a comprehensive benefits package. If you are ready to lead, mentor, and advance the science of pharmacometrics in partnership with innovative biomedical organizations, we encourage you to apply.

Requirements

PhD in pharmaceutical sciences, pharmacokinetics, mathematics, statistics, biomedical engineering, or a related discipline, or a Master’s degree with substantial relevant experience
8+ years of postgraduate experience in modeling and simulation
Demonstrated experience leading individuals or teams
Strong mentoring and coaching skills
Deep expertise in PKPD and pharmacometrics within drug development
Proficiency in tools such as NONMEM, MONOLIX, STAN
Experience with R, SAS, or similar statistical programming platforms
Experience with Bayesian data analysis
Excellent written and verbal communication skills
Ability to collaborate effectively across multidisciplinary teams

Responsibilities

Lead and mentor a group of PKPD modeling and simulation scientists
Support the professional growth and scientific development of team members
Design and implement quantitative, data driven pharmacometric strategies to guide drug development programs
Perform and oversee modeling and simulation analyses supporting clinical trials and regulatory strategy
Provide strategic drug development consultation and technical guidance to clients
Contribute to business development through project scoping and proposal preparation
Prepare and deliver reports and presentations for internal and external audiences
Present and publish scientific findings
Participate in company training initiatives as an instructor or contributor
Advance the scientific and strategic goals of the organization