About the position
Pioneering Medicines is seeking an innovative, motivated, and highly collaborative Senior Research Associate/ Associate Scientist to join our Translational Sciences team. The position supports translational research activities aimed at bridging the gap between early research and clinical development. This role will be directly accountable on data delivery to support the deep characterization of novel and emerging drug candidates, and/or execution of biomarker assays to evaluate pharmacology of therapeutic molecules. The candidate will be supported by scientific leaders to develop experience and expertise in drug discovery and pharmacology. We are looking for adaptive and scientifically curious individuals who embrace our core values of putting people and patients first, in an environment that encourages growth and learning. This position is on-site in Cambridge.
Responsibilities
- Deliver impactful datasets to inform the translational direction of drug discovery program(s) (e.g., pharmacodynamic biomarker discovery for disease/patient selection, inform human dose predictions, develop novel biomarker assays)
- Contribute to drug discovery programs supporting translational research goals and strategies.
- Collaborate on capability building to support translational needs and emerging program needs.
- Communicate research plans and data to colleagues with diverse scientific backgrounds.
- Maintain experimental records in an ELN
- Contribute to other prioritized activities and initiatives within the drug discovery group, aligned with team needs and personal interests.
Requirements
- Bachelor or Master of Science degree in biology, immunology, pharmacology or equivalent with a minimum of 2 years’ experience in a laboratory of academia or industry. Industrial experience is preferred.
- Previous experience with ex-vivo assay development in rodent, NHP and human tissues/plasma/whole blood required.
- Experience working with sterile cell culture techniques for the growth and maintenance of cell lines and primary cells (e.g. peripheral blood mononuclear cells, organoids, explant cultures).
- Prior working experience with in vitro cell based pharmacology assays using human or rodent primary cells.
- Hands-on experience with isolating and manipulating primary cells to perform downstream analysis through techniques such as (but not limited to) MSD/ELISA, FACS, western blots, qPCR, histology, fluorescence microscopy.
- Experience with scientific software (e.g., GraphPad PRISM, imaging software).
- Independence in experimental design and execution, data analysis, interpretation, and presentation of in vitro/in vivo study analysis with ability to work efficiently and productively in a highly dynamic environment.
- Team player with a demonstrated ability to collaborate across disciplines.
- Must be an organized and efficient multitasker with excellent ability to clearly communicate scientific data orally as well as via detailed documentation of experimental results via ELN.
Nice-to-haves
- Preclinical research experience that supports early phase clinical studies or is directly related to the understanding of human disease/pharmacology.
- Experience with advanced cell biology techniques (organoid cultures, 3D cell culture models, iPSC manipulation) for use in pharmacology/translational research.
- Experience/understanding in the utility of bioinformatics to inform translational research directions.
