The Pilot-in-Command (PIC) is accountable for the safe conduct of assigned flights. The PIC is responsible for the operation, safety and security of the aircraft and the safety of all crew members, passengers and cargo on board. Specific duties and responsibilities include ensuring that a flight will not be commenced if a flight crew member is incapacitated from performing duties by any cause such as injury, sickness, fatigue, or the effects of any psychoactive substance. The PIC must also ensure that the flight will not be continued beyond the nearest suitable aerodrome or heliport when a flight crew member's capacity to perform functions is significantly reduced by impairment of faculties from causes such as fatigue, sickness or lack of oxygen. Other responsibilities include operational control, security of the aircraft, checking weather and NOTAMs, determining fuel and oil requirements, ensuring aircraft airworthiness, completing pre-flight inspections, and operating the aircraft in accordance with company procedures.