The Mayo Clinic Program in Precision Genomics: Interventional Therapeutics

Mayo Clinic • Rochester, MN

45d

About The Position

Mayo Clinic and its Department of Clinical Genomics , as well as other aligned Departments and Programs, are seeking exceptional physicians and scientists, experts in the rapidly evolving field of genome editing and therapeutic delivery, to drive innovation at the intersection of discovery, translational, clinical research, and clinical practice to join our new and rapidly evolving Program in Precision Genomics: Interventional Therapeutics (PG-IT). The PG-IT program at Mayo Clinic is a groundbreaking new initiative of highly innovative and creative scientists and physicians working collaboratively to advance next-generation molecular therapies by delivering genetically targeted treatments in vivo. We are building an accomplished team of leaders including scientists driving innovation in genome editing and physicians who can deliver customized new and novel genetic therapies to the patients we serve. We are seeking candidates who excel in collaborative, team-oriented environments and demonstrate a strong commitment to advancing genomic medicine for improved patient outcomes. Qualified candidates joining the PG-IT program will collectively possess expertise in rare and complex disease genetics and genomics, clinical-grade genomic sequencing, multi-omic investigations, interventional human genetics, functional genomics, innovative molecular therapeutics, and human interventions and clinical trials, including single patient expanded access investigational new drug (IND) development processes. These candidates will join our efforts to develop a comprehensive institutional program that unites laboratory discovery, clinical genomics, informatics, and precision therapeutics, thereby delivering transformative advancements for patients affected by genetic and genomic disorders, including rare, inherited and complex disorders and diseases.
The PG-IT program will build on tremendous strengths at Mayo Clinic including: The Mayo Clinic Artificial Intelligence (AI) Program, driving the development of AI-based drug discovery, predictive models, large language models (LLMs), and AI agents within research and implemented into the Mayo Clinic clinical practice, powered by unparalleled partnerships and compute capabilities (NVIDIA SuperPOD DGX B200). Mayo Clinic Platform (MCP; www.mayoclinicplatform.org ), the world's largest distributed federated healthcare data network with cloud-based storage of the fully digitized longitudinal patient records (including fully digitized radiographic images and pathology slide images, and sophisticated laboratory diagnostics) and associated research data and biospecimens from >50M patients at Mayo Clinic and MCP partners worldwide. Exceptional research and clinical programs, research infrastructure, shared research resources, and education and training programs to facilitate research in basic and clinical genomics and molecular engineering to precisely target genetic drivers of rare and complex conditions. A robust clinical research and clinical trials infrastructure that currently supports the delivery of the nation’s largest number of clinical trials to the patients we serve, including new and novel and “first in human” therapies, including cellular, biologic, and genetic therapies. Mayo Clinic’s unique collaborative ecosystem, which includes an integrated clinical practice, world-class research platforms, and advanced infrastructure for gene and cell-based therapeutic development.
Our goals for the Mayo Clinic PG-IT program include in vivo human gene editing for rare and inherited genetic disorders and complex human diseases, the acceleration of drug repurposing for genetically targeted indications, and identifying the most promising novel gene-editing interventions to benefit patients. This will help accelerate discovery and apply cutting-edge innovations in real-world settings. Areas of opportunity span therapeutic development, CRISPR- and RNA-based interventions, genome engineering, molecular diagnostics, novel mechanisms and modes of delivery of genetic therapies in vivo, and the deployment of genomics-enabled clinical care pathways for rare, inherited, and complex conditions. Successful candidates will lead, design, and implement innovative genomic and translational approaches that improve patient outcomes while driving forward to the next generation of therapeutic and diagnostic discovery. These roles offer the opportunity to collaborate across Mayo Clinic’s extensive research and clinical networks, including partnerships with the Mayo Clinic Laboratories, the Advanced Diagnostics Laboratory, extensive biopharma partnerships and collaborations, and enterprise-wide precision medicine initiatives. Faculty will contribute to the development and integration of emerging genomic technologies into clinical and therapeutic pipelines, helping to shape programs that influence local, national, and global practice in genomic medicine. As the PG-IT Program builds it will gain SAGE (Standards for Advanced Gene Editing) certification for the customized delivery of human genetic interventions.
Mayo Clinic’s values of teamwork, collaboration, and patient-centered care are foundational to deliver integrated research, medical, and surgical care for individuals with complex genetic and genomic conditions. Faculty members will receive academic appointments (Assistant, Associate, Full Professor and Consultant) within the Mayo Clinic College of Medicine and Science commensurate with experience, scholarly contributions, and leadership in clinical, research, or translational domains. Mayo Clinic is committed to supporting the long-term success of faculty through robust research infrastructure, interdisciplinary mentorship, and a culture that values innovation, scientific excellence, and transformative patient impact. We are enthusiastic about the potential to work with visionary leaders in the field and look forward to the opportunity to make significant strides in genomic medicine together.
The Department of Clinical Genomics at Mayo Clinic is a national leader in integrating advanced genomic science with patient‑centered clinical care. Our mission is to individualize medicine through the development and application of cutting‑edge genomic technologies that enable the prediction, prevention, diagnosis, and treatment of both rare and common genetic conditions. By generating deep insights into each patient’s genomic architecture, our teams drive innovative care strategies that improve outcomes and shape the future of precision medicine. Clinical Genomics supports a broad spectrum of services, including comprehensive family history assessments, risk evaluations for hereditary conditions, and whole‑exome, whole‑genome, and multi‑omic testing for complex and rare disorders. These programs are tightly integrated with enterprise‑wide research and clinical resources, providing faculty with unparalleled access to world‑class platforms in sequencing, functional genomics, bioinformatics, and emerging therapeutic modalities. Our department operates through a highly collaborative, multidisciplinary model, bringing together medical geneticists, PhD scientists, certified genetic counselors, nurses, and allied specialists across Mayo Clinic’s practice and research environment. This seamless integration enables faculty to evaluate virtually any genetic condition, coordinate advanced diagnostic workflows, and partner with teams across the institution to translate discovery into meaningful clinical impact. For faculty, Clinical Genomics is an enterprise department spanning the three Mayo Clinic sites of Rochester, Florida, and Arizona, and offers a dynamic and supportive environment in which to build innovative research programs, engage in transformative clinical initiatives, and contribute to Mayo Clinic’s enterprise commitment to advancing genomic medicine. Faculty benefit from strong institutional support, access to robust research infrastructure, the opportunity to collaborate across multiple campuses, and the ability to contribute to initiatives that influence care on a national and global scale.
For over 160 years, the mission of Mayo Clinic has been to inspire hope and to promote health and healing through the integration of clinical practice, research, and education on behalf of the patients, communities, and learners we serve from across the nation and the world. Each of Mayo Clinic’s three Destination Medical Center (DMC) campuses in the United States are fully engaged in clinical practice, innovative research, and education and training. These three campuses – referred to as the Mayo Clinic enterprise - include Rochester, Minnesota (MCR); Jacksonville, Florida (MCF); and Phoenix and Scottsdale, Arizona (MCA). In addition, Mayo Clinic fully owns and operates a community-based rural health care delivery system (the Mayo Clinic Health System; MCHS) which extends through 49 rural communities in southern Minnesota, western Wisconsin, and northeastern Iowa. For the past eight years, Mayo Clinic has been ranked as the No. 1 health system in the nation and the world, with the most #1 ranked medical specialties, by U.S. News & World Report, Newsweek, and other healthcare quality organizations. Each of the Mayo Clinic hospitals on the three Mayo Clinic campuses have also been consistently ranked as the #1 hospital and the #1 cancer center and cancer hospital in their respective state. Mayo Clinic also has the largest integrated organ transplant program in the nation and conducts more clinical trials driving research and testing new therapies and interventions compared to any other institution in the United States. In 2025, with a staff of more than 85,000, including more than 7,300 physicians and scientific investigators, Mayo Clinic cared for more than 1.3 million unique patients who came from all 50 U.S. states and 135 countries.
Health care has operated in an environment where patients have had the least control. Technology, data-driven knowledge, artificial intelligence (AI), consumerism, and “platform thinking” will establish the next generation of health care. To thrive in this environment, healthcare organizations must break through the old paradigm and transform scientific research and healthcare access and delivery on behalf of the patients we serve. By remaining true to its primary value, "the needs of the patient come first," and the RICH TIES core values of Respect, Integrity, Compassion, Healing, Teamwork, Innovation, Excellence, Stewardship, Mayo Clinic is driving the transformation of biomedical research and health care through its 2030 Bold. Forward. Strategic Plan with the framework Cure, Connect, and Transform.

Requirements

• PhD or equivalent degree with post-doctoral training in relevant scientific fields
• Demonstrated expertise in genetics and genomics in human cells and tissues and/or in relevant model systems
• Experience in developing or applying human and other model systems or disease‑specific cellular platforms
• Proven record of scholarly productivity, including high quality peer‑reviewed publications and peer-reviewed funding and/or industry funding (or clear potential to gain future funding) leading to impactful research contributions
• Demonstrated creativity and innovation
• Ability to contribute to translational genomics programs that integrate discovery science with clinical or therapeutic applications
• Strong communication skills with the ability to collaborate across scientific, clinical, and operational teams
• Commitment to Mayo Clinic’s values including teamwork, integrity, innovation, and patient‑centered care
• Board-certified MD, MD/PhD, or equivalent clinical degree with experience in clinical genetics and/or genomics
• Expertise in multiple human gene‑editing or therapeutic genomics modalities and in in vivo therapeutic delivery
• Proven record of scholarly productivity, including high quality peer‑reviewed publications and sustained peer-reviewed funding and/or industry funding leading to impactful research contributions
• Demonstrated creativity and innovation
• Proven track record in innovative translational and clinical research including novel therapeutics and therapeutic development and in the design and conduct of human clinical trials, particularly early phase and first-in-human human clinical trials and single patient INDs.
• Demonstrated academic leadership in research and clinical practice and program‑building expertise
• Demonstrated ability to develop strategies and drive multidisciplinary teams to success

Nice To Haves

• Experience working in collaborative, multidisciplinary research or clinical environments
• Experience in teaching and mentoring
• Experience participating in multi‑institutional research networks or other large, collaborative scientific initiatives
• Experience in teaching and mentoring

Responsibilities

• Lead, design, and implement innovative genomic and translational approaches that improve patient outcomes while driving forward to the next generation of therapeutic and diagnostic discovery.
• Contribute to the development and integration of emerging genomic technologies into clinical and therapeutic pipelines, helping to shape programs that influence local, national, and global practice in genomic medicine.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree