Vertex Pharmaceuticals-posted 7 days ago
Full-time • Entry Level
Onsite • Boston, MA
5,001-10,000 employees

We are seeking a talented, self-motivated and collaborative in-vivo pharmacologist to join the integrated pharmacology team supporting late-stage drug discovery. The ideal candidate will have a strong foundation in pharmacology, work with a high degree of independence and be adept at conceptually designing, executing and interpreting in vivo/ex vivo experiments to establish therapeutic proof-of-concept across diverse disease areas.

  • Designs and conducts elaborate, conceptually connected, multi-component in vivo/ex vivo experiments to demonstrate proof-of-concept in preclinical disease models including pharmacokinetic, pharmacodynamic and efficacy relationships.
  • Perform advanced and/or complex experimental assay development and troubleshooting.
  • Collates and interprets complex data systematically and synthesizes results into a cohesive body of conclusions or recommendations to guide Project decisions and new research activities.
  • Exercises solid judgment to prioritize studies, considering feasibility and Project impact.
  • Scours relevant scientific literature and routinely incorporates new insights into research activities.
  • Identifies, prioritizes and introduces relevant emerging technologies in their field of expertise to advance the existing technology platforms and create/maintain a competitive advantage.
  • Explores the feasibility of applying new scientific principles/concepts or implements and validates novel experimental approaches and technologies to achieve project goals.
  • Contributes significantly to patent and/or publication preparation.
  • Independently prepares study presentations and presents experimental conclusions at internal Group/Department or Project Team research meetings.
  • Performs other duties as assigned.
  • Designs and executes complex, well controlled, challenging experiments that measure the action of compounds on in vivo/ex vivo disease biology assays.
  • Maintains a broad working knowledge of fundamental pharmacology principles.
  • Demonstrates astute understanding of his/her own discipline and the relevant literature.
  • Maintains a high level of knowledge related to current developments in the scientific Project field.
  • Displays proven productivity and experimental creativity, and effective dissemination of ideas.
  • Demonstrates effective, self-sufficient communication skills, especially in peer-directed presentations.
  • Demonstrates awareness of other Project-related disciplines and an understanding of general concepts and some experimental detail within those areas.
  • Must be proficient in rodent handling, dosing (IV, PO, IP, SC), blood collection (tail nick, submandibular, cardiac puncture) and tissue harvesting.
  • Demonstrate experience developing, executing and troubleshooting assays across a wide array of in vivo and molecular techniques (i.e. ELISA, qPCR, Western and flow cytometry).
  • Ability to rapidly learn and master new techniques and technologies.
  • Essential qualities include: integrity, flexibility, adaptability, organization and multi-tasking skills, excellent record keeping and the ability to function both independently and effectively as part of an interactive and cross-functional team.
  • Bachelor's degree in pharmacology or related biological sciences
  • Typically requires a PhD and 0-3 years of experience or,
  • Typically requires a Masters degree and 3 years of experience or,
  • Typically requires a Bachelors degree and 6 years of experience
  • This role is eligible for an annual bonus and annual equity awards.
  • Some roles may also be eligible for overtime pay, in accordance with federal and state requirements.
  • From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.
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