The St. Jude Fellowship in Pediatric Cancer Predisposition offers training in germline precision medicine, which holds great promise to optimize the clinical care of children with cancer. As such, it is critical that pediatric hematology/oncology practitioners understand and learn how to incorporate recent exciting yet complex discoveries surrounding germline genomics into the daily management of their patients. This one-year program provides fellows with advanced training in cancer genetics as well as ample research opportunities focused on hereditary predisposition to cancer.