Senior Oncology Trial Navigator

Natera • San Carlos, CA

1d

About The Position

The Oncology Trial Navigator will play a critical role in connecting Signatera patients to life-changing clinical trial opportunities. As a front-line clinical expert, you will be responsible for the end-to-end execution of patient matching workflows—from initial AI-enabled screening to successful enrollment at a clinical trial site.

You will serve as the primary clinical point of contact for external stakeholders, including treating oncologists, principal investigators (PIs), and research coordinators. This role combines deep oncology clinical knowledge with high-touch stakeholder engagement in a fast-scaling, mission-driven environment. You will work closely with the Senior Manager of Oncology Trial Navigation to pilot and refine the navigation service, providing the "on-the-ground" insights necessary to scale this function across the oncology domain.

Requirements

• Current, active licensure as a Registered Nurse (RN), Certified Genetic Counselor (CGC), Nurse Practitioner (NP), or Physician Assistant (PA).
• Must maintain licensure in good standing throughout employment.
• 3–5 years of oncology clinical experience, with at least 2 years specifically in oncology clinical research (e.g., as a Research Nurse, Coordinator, or Navigator).
• Proven experience in patient identification and trial matching services, ideally within a molecular diagnostics or biotech environment.
• Experience communicating complex clinical and genomic information to physicians, PIs, and patients.
• Strong clinical knowledge of oncology, with a focus on biomarker-driven therapies and MRD-based clinical trial landscapes.
• Expert-level understanding of clinical trial design and the ability to interpret complex inclusion/exclusion criteria.
• Technology Adoption: Ability to quickly master new AI-enabled matching tools and digital health platforms.
• Data Literacy: Comfort navigating large clinical datasets and translating patient records into structured eligibility requirements.
• Systems Advocacy: Proactive in identifying workflow inefficiencies and suggesting technological or process-based solutions.
• Exceptional communication and interpersonal skills.
• High degree of empathy and professionalism in patient-facing interactions.
• Strong organizational skills and follow through discipline.

Nice To Haves

• Board Certification (e.g., OCN, CCRC, or similar) is highly preferred.
• A master’s degree in a clinical or scientific field is preferred.

Responsibilities

• Conduct high-volume, structured outreach to oncologists, PIs, and research coordinators regarding trial-eligible patients identified through Natera’s platforms.
• Act as a clinical consultant to research sites, delivering patient eligibility notifications and facilitating seamless referral workflows.
• Track patient progression from initial identification through referral and enrollment, ensuring timely follow-up and resolution of site-level bottlenecks.
• Operationalize outputs from Natera’s AI-enabled trial matching platform to manage a daily priority queue of potential matches.
• Perform rigorous clinical reviews, reconciling patient molecular data (e.g., MRD status, biomarkers) and exome results with trial-specific inclusion/exclusion criteria.
• Collaborate with the Clinical Product team to provide real-time feedback on matching accuracy, helping to refine AI algorithms and data filters.
• Provide high-level, empathetic, and compliant education to patients regarding specific clinical trial opportunities and the clinical significance of their molecular results.
• Coordinate warm handoffs to site research teams, ensuring patients feel supported and informed throughout the referral process.
• Maintain meticulous documentation of all outreach and referral activities within CRM and tracking tools.
• Contribute to the continuous improvement of Standard Operating Procedures (SOPs).
• Participate in cross-functional collaboration with internal partners to optimize the field.

Benefits

• Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents.
• Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits.
• Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more.
• We also offer a generous employee referral program!

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Number of Employees: 501-1,000 employees