NGS Bioinformatician

Eli Lilly • San Diego, CA

411d • $156,750 - $250,800

About The Position

The NGS Bioinformatician at Eli Lilly and Company plays a crucial role in advancing the discovery of novel biologics through the analysis of next-generation sequencing (NGS) data. This position is part of the computational science team within the Lilly Biotechnology Discovery Research Center, which focuses on developing innovative biotherapeutics. The role requires a deep understanding of NGS data analysis, collaboration with research teams, and the ability to create and implement new workflows for various sequencing technologies.

Requirements

• Ph.D. in bioinformatics, computational biology, or similar field with a minimum of 3 years relevant experience in a Biotech/Pharmaceutical company.
• Proficiency in essential bioinformatics software and scripting languages (e.g., Python, R, Perl etc.).

Nice To Haves

• Thorough knowledge of modern sequencing technique procedures (Sanger, NGS, 10x Genomics, PacBio, Nanopore), with extensive experience in independent data processing.
• Highly experienced with various NGS data processing tools, including quality control, trimming and filtering, alignment, assembly, annotation and visualization etc.
• Familiar with coding packages to number, align and annotate antibody or related biologics sequences.
• Sophisticated in data visualization and presenting results in statistical and scientific formats.
• Well experienced in customizing and coding to build new sequencing data analysis workflows from scratch.
• Experienced in building sequence libraries based on pre-defined rules, statistical learnings and AI/ML prediction filtering.
• Experience mining data from open-source sequence databases like IMGT, NCBI, GenBank, OAS, PDB, SABDAB, etc.
• Experienced extracting useful information from small to large datasets for the application of AI/ML in biologics discovery, collaborating with AI/ML teams to apply the learning to research projects.
• Familiar with the sequences and structures of different types of biologic therapeutic molecules. Deep understanding of the relationships between sequence and structure and structure and function.
• Experience supporting biologics projects from Discovery to Lead Optimization.

Responsibilities

• Support Lilly research teams and projects with NGS data analysis including antibodies, proteins, single-cell RNA, peptides, and beyond.
• Deliver processed results with good quality in a timely manner.
• Develop new workflows for different types of sequencing results such as bulk NGS, 10x Genomics, PacBio and Nanopore, based on project needs.
• Collaborate with members from the computational science team and technology team to design and deliver customized antibody/VHH/mini-protein libraries.
• Create data analysis and visualization methods to interpret results, inspire and enable data-driven AI/ML based drug discovery.
• Work with Lilly data capture team members, properly manage raw and processed data in efficient and convenient ways.
• Bring up new ideas to best utilize internal and public sequence database for new applications.

Benefits

• Eligibility to participate in a company-sponsored 401(k)
• Pension
• Vacation benefits
• Eligibility for medical, dental, vision and prescription drug benefits
• Flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts)
• Life insurance and death benefits
• Certain time off and leave of absence benefits
• Well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Industry: Chemical Manufacturing
• Education Level: Ph.D. or professional degree