Microglia Scientist

Retro•Redwood City, CA

5d•$130,000 - $170,000

About The Position

Retro develops therapies for diseases driven by the biology of aging. We focus on cellular reprogramming and autophagy to rejuvenate cell and tissue function with the ultimate aim of adding 10 years to healthy human lifespan. We are seeking an experienced new member of our Microglia Therapeutics team who will bring well-rounded experience working in Alzheimer’s disease research to help us bring our cell therapy to the clinic! About you: You approach your work with a growth-mindset, eager to use your critical thinking skills and problem solving abilities. You enjoy hands-on work and value being honest, organized, and paying attention to details. You’re a highly collaborative team member with a “can-do” attitude and great communication skills. In this role you will: Design and execute experiments to support our research goals. Perform regular culture and differentiation of iPSCs to multiple CNS cell types using aseptic tissue culture techniques. Troubleshoot and optimize 2D and 3D (organoids) differentiation protocols. Develop cell-based and molecular assays to characterize the cells and prove function. Collaborate seamlessly within the Microglia Team and across Retro teams such as In-Vivo, Computational Biology, Automation, Process Development, etc. Help the team solve technical challenges and suggest mitigation strategies. Actively participate in brainstorming sessions to develop adaptive strategies for overcoming obstacles. Analyze, interpret and present experimental data to our internal teams and collaborators. Maintain an organized electronic lab notebook and contribute to supporting documents. Participate in regular lab organization activities and ordering.

Requirements

Have a Ph.D. in Neuroscience, Biology or related field and at least 3 years of relevant post-degree experience in academia or industry.
3+ years of experience working on Alzheimer’s Disease research.
Are familiar with neurodegenerative diseases and ways to accurately model different aspects of neuropathology.
Experience with iPSC tissue culture, cell-based assays and in vivo models of neurobiology.

Nice To Haves

Have experience with differentiation of iPSCs to brain cell-types

Responsibilities

Design and execute experiments to support our research goals.
Perform regular culture and differentiation of iPSCs to multiple CNS cell types using aseptic tissue culture techniques.
Troubleshoot and optimize 2D and 3D (organoids) differentiation protocols.
Develop cell-based and molecular assays to characterize the cells and prove function.
Collaborate seamlessly within the Microglia Team and across Retro teams such as In-Vivo, Computational Biology, Automation, Process Development, etc.
Help the team solve technical challenges and suggest mitigation strategies.
Actively participate in brainstorming sessions to develop adaptive strategies for overcoming obstacles.
Analyze, interpret and present experimental data to our internal teams and collaborators.
Maintain an organized electronic lab notebook and contribute to supporting documents.
Participate in regular lab organization activities and ordering.