Medical Director

4D Molecular Therapeutics

13d

About The Position

4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery GENERAL SUMMARY: The Medical Director will lead the design, execution, and analysis of clinical trials in the Ophthalmology therapeutic area, with a focus on retina programs. This role provides strategic and operational clinical leadership across cross-functional study teams and serves as a key medical expert internally and externally.

Requirements

Medical Degree (M.D.), OD, PhD, PharmD or equivalent
Residency training in Ophthalmology with a preference for subspecialty training in retina
5+ years of clinical ophthalmology research in the biopharmaceutical industry
Experience with Phase 3 retina clinical trials
Experience writing clinical research protocols and acting as a medical monitor
Experience in data analysis, data interpretation, and medical writing
Knowledge of ICH-GCP and FDA regulatory guidelines.
Effective written and verbal communication skills, including public speaking

Nice To Haves

Board certification a plus
Retina fellowship training a plus
Experience with gene therapy a plus.
Experience in other phases (Phase 1, 2, 4) of clinical research a plus.
Experience with NDA/BLA/MAA submission a plus.
Knowledge of international regulatory guidelines a plus.

Responsibilities

Lead clinical strategy and execution for ophthalmology trials, including protocol development, study oversight, and data interpretation.
Serve as medical monitor for clinical studies, ensuring patient safety and data integrity.
Author and review clinical documents including protocols, IBs, ICFs, INDs, CSRs, and regulatory submissions.
Collaborate with cross-functional teams (clinical operations, regulatory, biometrics, safety, CMC, commercial) to drive program success.
Engage with external experts, organize advisory boards, and contribute to scientific and medical communications.
Identify and mitigate clinical and programmatic risks.
Support portfolio development and evaluation of new clinical opportunities.
Represent the company in regulatory and scientific forums as needed.

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